By Brian S. Fulton
With dependancy a key goal for drug discovery efforts, this e-book fills an immense and well timed want for medicinal chemists who have to comprehend advanced neuroscience matters. the writer illustrates medicinal chemistry's well known position in treating habit and covers particular medications of abuse together with narcotics, stimulants, depressants, nicotine, and marijuana.
• Interprets complicated neuro- organic and pharmacological info, just like the drug-reward process, for medicinal chemists
• Emphasizes neurotransmitters and neurochemical mechanisms of addictive drugs
• Pulls jointly info at the many capability drug goals for treating addiction
• Stresses specific medicinal chemistry difficulties while describing pharmacology trying out tools and drug development
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Additional resources for Drug Discovery for the Treatment of Addiction : Medicinal Chemistry Strategies
8 Our goal will be to gain a basic understanding of neuroanatomical aspects of the brain and the reward system to more fully understand and interpret pharmacological studies of drugs of addiction. Drug Discovery for the Treatment of Addiction: Medicinal Chemistry Strategies, First Edition. Brian S. Fulton. © 2014 John Wiley & Sons, Inc. Published 2014 by John Wiley & Sons, Inc. 18 THE REWARD SYSTEM 19 In general, the physiological etiology of diseases of the central nervous system (CNS) can be ascribed to dysfunctions of certain regions of the brain.
2. We will now look at each major neurocircuitry system in the CNS specifically with regard to addiction. From this, an understanding of approaches toward the treatment of addiction will develop. The goal of this section is to provide a solid neurochemical mechanistic understanding of how addictive drugs work and the identification of potential targets to treat addiction. 1 Glutaminergic System in Drug Addiction Glutamate-containing neurons are widely distributed throughout the brain. 9. Of particular importance to addiction are a bundle of neurons between the cortex and the striatum called the corticostriatal circuit that is modulated by glutamate.
This is certainly true for drug addiction. 2 33 Neurocircuits Neurocircuitry system Neurotransmitter Receptors Glutaminergic (excitatory) Glutamic acid Ionotropic ion channels NMDA, AMPA (Na+ ), KA (Na+ ) Metabotropic glutamate receptors mGlu1–mGlu8 GABAergic (inhibitory) γ-Aminobutyric acid GABAA and GABAB ion channels Cholinergic Acetylcholine Muscarinic GPCRs M1 –M5 Nicotinic Na+ channels (NAChR) Adrenergic Norepinephrine α- and β-adrenergic receptors Norepinephrine transporter Dopaminergic Dopamine Dopamine receptors D1 –D5 Dopamine transporter Serotonergic Serotonin Serotonin receptors 5-HT1 –5-HT7 Serotonin transporter date, no magic target that can be hit with a magic bullet has been discovered.