By George Barger
163 pages, fifty four figures
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Additional info for The Alkaloids of Ergot
B arger : The Alkaloids of Ergot. concentration of ergotoxine by O d a 1; lower concentrations of ergotoxine (10 ~7 and 10 ~6) had a slight stimulant effect. A msler suggests that the inverted effect of adrenaline is due to this drug stimulating the vagus endings which stimulation however only becomes evident after the antagonistic sympathetic has been paralysed. The inverted effect of adrenaline is prevented by atropine, but the slight depression of the heart by ergotamine alone is not so prevented.
Action on the Uterus. The great activity of the ergot alkaloids on the isolated uterus was first discovered by Spiro4 in the case of ergotamine, and since ergo- Fig. 17. Two uterine horns of a virgin guinea-pig. Action of ergotoxine and ergotamine 1:12 5 ,0 0 0 ,0 0 0 . ) toxine had not been closely studied in this respect, there was at first an impression that it was less active. 25X 108 (see fig. : Cit. p. 99. A. , and E. O. M ’ C r e a : Quart. J. exper. Physiol. 20, 379 (1930). 3 M a c h t , D.
Toxine had not been closely studied in this respect, there was at first an impression that it was less active. 25X 108 (see fig. : Cit. p. 99. A. , and E. O. M ’ C r e a : Quart. J. exper. Physiol. 20, 379 (1930). 3 M a c h t , D. : Cit. p. 126. 4 S p i r o , K . : Schweiz, med. Wschr. 2, 737 (1921). 5 D a l e , H. , u. K. S p i r o : Cit. p. 106. 1 St r e u l i, 2 M acdonald, Action on the Uterus. 131 (see fig. 25 x 107. Schübel and Gehlen 1 likewise found ergotoxine and ergotamine to be qualitatively and quantitatively equivalent in their effects on the puerperal ca t’s uterus.