Drug Delivery: Principles and Applications (Wiley Series in by Binghe Wang, Longqin Hu, Teruna J. Siahaan

By Binghe Wang, Longqin Hu, Teruna J. Siahaan

An integral software for these operating on the entrance traces of latest drug developmentWritten for busy pros on the vanguard of latest drug improvement, Drug supply will get readers speedy in control on either the foundations and most modern functions within the more and more very important box of drug delivery.Recent advancements in such parts as combinatorial chemistry, proteomics, and genomics have revolutionized researchers' skill to quickly determine and synthesize new pharmacological compounds. despite the fact that, delivery-related houses stay an important explanation for medical trial failures.Bringing jointly contributions by means of top overseas specialists, Drug supply covers the total box in a scientific yet concise method. It starts off with an in-depth evaluation of key basics, equivalent to physiochemical and organic limitations; drug supply pathways; metabolism; drug formula; pharmacokinetic and pharmacodynamic matters; and extra. the rest of the publication is dedicated to the systematic examination-including overviews, well timed examples, and broad references-of a number of particular matters, including:* Receptor-mediated drug supply* Prodrug supply methods* Oral protein and peptide drug supply* Gene treatment and gene supply* Ultrasound-mediated drug supply* Polycationic peptides and proteins in drug supply* Pulmonary drug supply* Antibody-directed drug supply* Efflux transporters in drug excretion* highbrow estate matters in drug supply

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Extra resources for Drug Delivery: Principles and Applications (Wiley Series in Drug Discovery and Development)

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Monocarboxylic Acid Transporter Systems for transporting monocarboxylic acids such as lactic acid, acetic acid, and ketone bodies both into and out of the CNS are abundant in the BBB. The best-characterized organic acid transporter in the BBB is the monocarboxylic acid transporter (MCT). The MCT has been detected on both the luminal (blood) and ablumenal (brain) plasma membranes of brain capillary endothelial cells103 and likely participates in the bidirectional transport of organic acids into and out of the brain.

Aungst, B. J. J. Pharm. Sci. 1993, 82, 979–987. Okumu, F. ; Pauletti, G. ; Vander Velde, D. ; Siahaan, T. ; Borchardt, R. T. Pharm. Res. 1997, 14, 169–175. Lutz, K. ; Siahaan, T. J. J. Pharm. Sci. 1997, 86, 977–984. ; Awazu, S. J. Pharm. Sci. 1996, 85, 854–857. ; Quan, Y. ; Muranishi, S. J. Pharm. Sci. 1996, 85, 858–862. ; Audus, K. ; Siahaan, T. J. Brain. Res. 1997, 747, 103–113. Lutz, K. ; Siahaan, T. J. Drug Deliv. 1997, 10, 187–193. Makagiansar, I. ; Audus, K. ; Siahaan, T. J. Pharm. Res. 2001, 18, 446–453.

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