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Additional resources for Who Gave Pinta to the Santa Maria?: Torrid Diseases in a Temperate World
Bellmunt J, Allende E, Navarro M, et al. (1989) Epithelioid hemangioendothelioma of the liver with myocardial metastases. Jpn J Clin OncoI19:153-158 18. Bijsterbosch MK, Donker W, van de Bilt H, et al. (l996) Quantitative analysis of the targeting of mannose-terminal glucocerebrosidase. Predominant uptake by liver 44 E. Wisse et al. endothelial cells. Eur J Biochem 237:344-349 19. Bijsterbosch MK, Manoharan M, Rump ET, et al. (1997) In vivo fate of phosphorothioate antisense oligodeoxynucleotides: predominant uptake by scavenger receptors on endothelial liver cells.
Braet FCP, Kalle WHJ, de Zanger RB, et al. (1996) Comparative atomic force and scanning electron microscopy: an investigation on fenestrated endothelial cells in vitro. J Microsc 181:10-17 26. Braet F, de Zanger RB, Jans D, et aI. (1996) Microfilament-disrupting agent latrunculin A induces and increased number of fenestrae in rat liver sinusoidal endothelial cells: comparison with cytochalasin B. Hepatology 24:627-635 27. Brauneis U, Gatmaitan Z, Arias 1M (1992) Serotonin stimulates a Ca2+ permeant nonspecific cation channel in hepatic endothelial cells.
The most accurate measurements of fenestrae diameter have been performed with TEM preparations; SEM specimens shrink during preparation and change their measures by about 30%. , porosity) in SEM preparations  . In SEM preparations, fenestrae diameter decreases from III nm to 105 nm on a periportal-topericentral gradient, whereas the number varies from 9 to l3 per ~m2 in the same FIG. 10. SEM micrograph of an endothelial cell treated with latrunculin A, showing a substantially increased number of fenestrae.