Liver Diseases and Hepatic Sinusoidal Cells by Kyuichi Tanikawa (auth.), Kyuichi Tanikawa M.D., Takato Ueno

By Kyuichi Tanikawa (auth.), Kyuichi Tanikawa M.D., Takato Ueno M.D. (eds.)

Hepatic sinusoidal cells reminiscent of sinusoidal endothelial cells, Kupffer cells, hepatic stellate cells, and pit cells play an immense position in hemodynamic and metabolic functionality and are eager about a variety of liver illnesses. The widespread involvement of sinusoidal cells in pathologic stipulations is defined by means of the varied activities of these cells, an figuring out of that is necessary to clinicians. Generously illustrated, this quantity provides result of fresh experiences on hepatic sinusoidal cells in liver ailments, with an creation to the constitution and serve as of some of the kinds of sinusoidal cells. The in-depth concentration of the booklet is at the position of hepatic sinusoidal cells with regards to liver damage and regeneration, hepatic sinusoidal microcirculation, alcoholic liver illnesses, hepatic fibrosis, liver tumor, liver transplantation, cholestasis, and congenital lipidosis, therefore delivering a invaluable reference resource for practitioners and researchers.

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Bellmunt J, Allende E, Navarro M, et al. (1989) Epithelioid hemangioendothelioma of the liver with myocardial metastases. Jpn J Clin OncoI19:153-158 18. Bijsterbosch MK, Donker W, van de Bilt H, et al. (l996) Quantitative analysis of the targeting of mannose-terminal glucocerebrosidase. Predominant uptake by liver 44 E. Wisse et al. endothelial cells. Eur J Biochem 237:344-349 19. Bijsterbosch MK, Manoharan M, Rump ET, et al. (1997) In vivo fate of phosphorothioate antisense oligodeoxynucleotides: predominant uptake by scavenger receptors on endothelial liver cells.

Braet FCP, Kalle WHJ, de Zanger RB, et al. (1996) Comparative atomic force and scanning electron microscopy: an investigation on fenestrated endothelial cells in vitro. J Microsc 181:10-17 26. Braet F, de Zanger RB, Jans D, et aI. (1996) Microfilament-disrupting agent latrunculin A induces and increased number of fenestrae in rat liver sinusoidal endothelial cells: comparison with cytochalasin B. Hepatology 24:627-635 27. Brauneis U, Gatmaitan Z, Arias 1M (1992) Serotonin stimulates a Ca2+ permeant nonspecific cation channel in hepatic endothelial cells.

The most accurate measurements of fenestrae diameter have been performed with TEM preparations; SEM specimens shrink during preparation and change their measures by about 30%. , porosity) in SEM preparations [230] . In SEM preparations, fenestrae diameter decreases from III nm to 105 nm on a periportal-topericentral gradient, whereas the number varies from 9 to l3 per ~m2 in the same FIG. 10. SEM micrograph of an endothelial cell treated with latrunculin A, showing a substantially increased number of fenestrae.

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