Textbook of Drug Design and Discovery by Kristian Stromgaard, Povl Krogsgaard-Larsen, Ulf Madsen

By Kristian Stromgaard, Povl Krogsgaard-Larsen, Ulf Madsen

Building at the good fortune of the former variants, the Textbook of Drug layout and Discovery, 5th Edition, has been completely revised and up to date to supply an entire resource of knowledge on all features of drug layout and discovery for college students of chemistry, pharmacy, pharmacology, biochemistry, and drugs. the data is gifted in an up to date assessment shape with an underlying and basic specialize in the tutorial aspects.

Beginning with an creation to drug layout and discovery, the 1st 8 chapters conceal molecular reputation, ligand-based drug layout, and biostructure-based drug layout. The authors additionally speak about drug-like homes and choice making in medicinal chemistry, chemical biology, typical items in drug discovery, and in vivo imaging in drug discovery.

The heart six chapters offer an summary of peptide and protein drug layout, prodrugs in drug layout and improvement, and enzyme inhibitors. The authors additionally battle through receptors (structure, functionality, and pharmacology), ion channels (structure and function), and neurotransmitter transporters (structure, functionality, and drug binding).

The following chapters tackle vital neurotransmitter structures, GABA and glutamic acid receptors and transporter ligands, acetylcholine, histamine, dopamine and serotonin, and opioid and cannabinoid receptors. The ebook concludes with an exam of overlooked ailments, anticancer brokers, tyrosine kinase receptors, and antibiotics.

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LɈland and Ulrik Gether Chapter 15 GABA and Glutamic Acid Receptor and Transporter Ligands Bente FrɈlund and Lennart Bunch Chapter 16 Acetylcholine Anders A. Jensen Chapter 17 Histamine Receptors Iwan de Esch, Henk Timmerman, and Rob Leurs Chapter 18 Dopamine and Serotonin Benny Bang-Andersen, Lena Tagmose, and Klaus P. BɈgesɈ Chapter 19 Opioid and Cannabinoid Receptors Rasmus P. Clausen and Harald S. Hansen Chapter 20 Neglected Diseases SɈren B. Christensen and Ib C. , Piet Herdewijn, and Anastassios Economou Index Š Preface Textbook of Drug Design and Discovery is meant to be used primarily in teaching at undergraduate and postgraduate level courses, where an insight into the complex process of the early drug design and discovery process is central.

Rev. Drug Discov. 14:111舑129. L. 2011. Principles of early drug discovery. Br. J. Pharmacol. 162:1239舑1249. A. 2003. Target discovery. Nat. Rev. Drug Discov. 2:831舑838. J. 2001. Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings. Adv. Drug Deliv. Rev. 46:3舑26. A. 2011. Synopsis of some recent tactical application of bioisosteres in drug design. J. Med. Chem. 54:2529舑2591. , and Greyson, D. 2011. The cost of drug development: A systematic review.

A. 2011. Synopsis of some recent tactical application of bioisosteres in drug design. J. Med. Chem. 54:2529舑2591. , and Greyson, D. 2011. The cost of drug development: A systematic review. Health Policy 100:4舑17. A. J. 1996. Bioisosterism: A rational approach in drug design. Chem. Rev. 96:3147舑3176. 1 ŠINTRODUCTION Molecular recognition is the foundation for the function of virtually any biological system. It relies on the existence of favorable interactions between two (or more) molecules which could be a neurotransmitter molecule and its protein receptor or an enzyme and its substrate.

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