By Sumie Yoshioka
Drug items are advanced combos of substances and excipients and, as such, their chemical and actual balance kinetics are advanced. This booklet discusses the soundness of those dosage types with preformulation experiences via to the reviews at the ultimate items. The ebook is meant for graduate scholars, researchers and pros within the box of Pharmaceutics and Pharmaceutical Chemistry.
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Example text
Allosteric effect of the lipophilic molecules of the organic solvent on the protein structure. Weak competition of toluene or hexanol with protein binding of dye anions has been observed (KARUSH, 1951). Although SCHELLMAN et al. (1954) assume competition effects to be smaller for n-heptane, it is now definitely established that n-alkanes, e. , butane, pentane and others, form association complexes with several pure proteins (WISHNIA, 1962; WISHNIA and PINDER, 1966). Interactions between hydrocarbons and proteins have been studied by MOHAMMADZADEH-K et al.
Basic Methods for Determination of Steroid-Protein Interactions 1963). If to the aqueous phase a protein is added which forms complexes with the solute, the concentration of the unbound solute in the aqueous phase decreases, and solute moves in from the organic phase to compensate for the decrease. If the partition coefficient, which pertains to the unbound solute in the two phases, remains unaffected by the presence of the protein, a determination of the new equilibrium concentration of the solute in the organic solvent allows calculation of the corresponding concentration of unbound ligand in the aqueous protein phase, and thus by difference that of the bound portion.
The similarity to the adsorption isotherm was then the closest approach to a quantitative treatment available. Although some of the methods introduced at the time have later been developed to useful quantitative procedures, others do not lend themselves readily for this purpose. For example, influence on surface tension (LECOMTE DU N OUY, 1922, 1928) is exerted by only a limited number of steroid compounds; this technique has played no further role in the investigation of steroid-protein interaction.