By Kenneth E. Avis, Atul J. Shukla, Rong-Kun Chang
content material: contain: advent to Coating, A. Shukla, R. Chang, & okay. Avis Sugar Coating, E. Brunson & J. Schirmer movie Coating, R. Campbell & G. Sackett Microencapsulation, R. Sparks, I. Jacobs, & N. Mason computerized Coating structures, G. Smith & J. Spencer cleansing & Validation of cleansing for covered Pharmaceutical items, W. corridor balance & quality controls, J. Addison & D. Wiggins
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Extra info for Pharmaceutical unit operations : coating
Sample text
A measured amount of so6. Graco Inc.. Minneapolis, MN. 7. Waukesha Cherry-Burrell, Delavan, Wt. 8. Moyno Industrial Products, Springfield, OH, 9. , Minneapolis, MN, 10. 9. Positive displacement piston pump. Courtesy of Graco Inc. lution is delivered with each revolution. Spray initiation can be ei ther manual or automated. The pump size should be determined by batch size; all system parameters, such as the maximum application per step, can be achieved in approximately 10 to 15 sec. Process Example The following automated sugar-coating illustration utilizes a HiCoater* Model H-100 (39 in.
A drying rate that is too fast causes the sugar to crystal lize into a larger crystalline structure with a rough surface texture. Color Coating Color coating is the application of a sugar syrup containing dis persed pigments of lake dyes and titanium dioxide. The goal of color coating is to achieve an evenly colored, smooth surface suitable for polishing to a glossy, elegant finish. The materials used to color coat tablets include sugar, water, lake dyes, titanium dioxide, and 30 Pharmaceutical Unit Operations-Coating modifiers such as gelatin or acacia.
The final few applications of color syrup should be of a small enough volume to just wet the sur faces of all the tablets before they are dried with exhaust air, thus achieving a very fine, smooth surface. 7. 6 _ Solutions 1. Sugar 2. U 3 . 0 10 4, Color Dispersion (70% solids) 5. 6 Solution Application Amount Solution Temperature Inlet Air Temperature Number of Applications Tablet Weight Gain 10-20 mL/kg of cores 50 O f 50 O f* 10--20 ~ 5 - 10% The failure of a coating to dry is a result of inversion of the sugar-coating solution.