Generic Drug Formulations by Volker Buhler

By Volker Buhler

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2 %) 1. Formulation I. II. s. 2 g 2. Manufacturing Heat mixture I to about 60 °C and add slowly the warm solution II (60 °C). 3. Properties of the solution Clear, colourless liquid having a low viscosity. 1%) 1. Formulation I. II. s. 99 g 2. Manufacturing Heat mixture I to about 60 °C, stirr well and add slowly the warm solution II. A clear solution is obtained. 3. Chemical stability (40 °C) No loss of alpha-Bisabolol after 3 months. 8 Liquid Formulations (Lab scale) Alpha-Bisabolol Ethanolic Mouth Wash Solution (1%) 1.

4 Formulation of granules, dry syrups and Iyophylisates (Lab scale) Albendazole Dry Syrup or Instant Granules (200 mg) 1. Formulation I. II. 2 g g g g g g 2. 8 mm screen, dry and sieve again. Fill 50 g of the granules in a 100 ml flask (= dry syrup) or 5 g in sachets (= instant granules) 3. Administration forms Dry syrup (200 mg albendazole /10 ml): Fill the flask containing 50 g of granules with water to the 100 ml mark. The obtained suspension has no bitter taste. Instant granules (200 mg albendazole sachet): Suspend 5 g of the granules (= 200 mg albendazol) in a glass of water.

9 Tablet formulations (Lab Scale) Acetylsalicylic Acid + Vitamin C Tablets (325 mg + 250 mg) 1. Formulations No. 2 g g g g g g g No. 2 325 g 250 g – 100 g 12 g 30 g 3g 2. 8 mm sieve, mix and press with medium/high compression force. 3. Tablet properties No. 1 No. 1% 726 mg 12 mm biplanar 100 N < 1 min 1% BASF Fine Chemicals Generic Drug Formulations 1998 4. Chemical stability of formulation No. 9 Tablet formulations (Lab Scale) Acetylsalicylic Acid Tablets (400 mg) 1. 15 g g g g 2. 8 mm sieve and press with low compression force.

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