By Volker Buhler
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The fourth quantity within the six-volume guide of Pharmaceutical production Formulations, this e-book covers semi-solid medicines. It comprises formulations of ointments, creams, gels, and suppositories, from publicly to be had yet commonly dispersed details from FDA New Drug purposes (NDA), patent purposes, and different resources of standard and proprietary formulations.
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Extra info for Generic Drug Formulations
2 %) 1. Formulation I. II. s. 2 g 2. Manufacturing Heat mixture I to about 60 °C and add slowly the warm solution II (60 °C). 3. Properties of the solution Clear, colourless liquid having a low viscosity. 1%) 1. Formulation I. II. s. 99 g 2. Manufacturing Heat mixture I to about 60 °C, stirr well and add slowly the warm solution II. A clear solution is obtained. 3. Chemical stability (40 °C) No loss of alpha-Bisabolol after 3 months. 8 Liquid Formulations (Lab scale) Alpha-Bisabolol Ethanolic Mouth Wash Solution (1%) 1.
4 Formulation of granules, dry syrups and Iyophylisates (Lab scale) Albendazole Dry Syrup or Instant Granules (200 mg) 1. Formulation I. II. 2 g g g g g g 2. 8 mm screen, dry and sieve again. Fill 50 g of the granules in a 100 ml flask (= dry syrup) or 5 g in sachets (= instant granules) 3. Administration forms Dry syrup (200 mg albendazole /10 ml): Fill the flask containing 50 g of granules with water to the 100 ml mark. The obtained suspension has no bitter taste. Instant granules (200 mg albendazole sachet): Suspend 5 g of the granules (= 200 mg albendazol) in a glass of water.
9 Tablet formulations (Lab Scale) Acetylsalicylic Acid + Vitamin C Tablets (325 mg + 250 mg) 1. Formulations No. 2 g g g g g g g No. 2 325 g 250 g – 100 g 12 g 30 g 3g 2. 8 mm sieve, mix and press with medium/high compression force. 3. Tablet properties No. 1 No. 1% 726 mg 12 mm biplanar 100 N < 1 min 1% BASF Fine Chemicals Generic Drug Formulations 1998 4. Chemical stability of formulation No. 9 Tablet formulations (Lab Scale) Acetylsalicylic Acid Tablets (400 mg) 1. 15 g g g g 2. 8 mm sieve and press with low compression force.