Pharmaceutical powder compaction technology by Metin Çelik, Metin Çelik

By Metin Çelik, Metin Çelik

''Revised to mirror sleek pharmaceutical compacting options, this moment version courses pharmaceutical engineers, formula scientists, and product improvement and caliber coverage group of workers throughout the compaction formula procedure and alertness. Compaction of powder elements either lively factor and excipients is tested to make sure constant and reproducible disintegration and dispersion profiles. Read more...

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Tensile strength or deformation hardness). For the production of such tablets the compressional stress sc needs to be important enough to induce plastic flow and/or brittle fracture of the primary granules or particles, that is, to produce simultaneously new surfaces and bonds in this dense powder compact. Process of Uniaxial Compression The usual tabletting machines work according to the principle of uniaxial compression. Thus the upper and lower surface areas of the tablet remain constant during the compression process; the thickness of the tablet is reduced with application of the compressional stress sz in the z-direction.

In attempting to apply a Maxwell rheological form directly to the entire compact, viscoplastic deformation was assumed. The subsequent decomposition of the creep compliance curve as interpreted by the authors has several contradictions. While the reciprocal slope of the compliance curve for a Maxwell fluid should provide an apparent viscosity, the shape of the experimental curve is clearly parabolic. The assumption of a Maxwell form is inappropriate; a higher order rheological model would be more suited to the curvature of the observed data.

J Eng Mater Technol 1992; 114(January):105–110. 31. Swinkels FB, Wilkinson DS, Artz E, et al. Mechanisms of hot-isostatic pressing. Acta Metall 1983; 31(11):1829–1840. 32. Lu GG, Shi X. Computer simulation of isostatic powder compaction by random packing of monosized particles. J Mater Sci Lett 1994; 13:1709–1711. 33. Nolan GT, Kavanagh PE. Random packing of nonspherical particles. Powder Technol 1995; 84: 199–205. 34. Yen KZY, Chaki TK. A computer simulation of rearrangement and compaction of particles under various internal and external stresses.

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