By Metin Çelik, Metin Ã‡elik
''Revised to mirror sleek pharmaceutical compacting options, this moment version courses pharmaceutical engineers, formula scientists, and product improvement and caliber coverage group of workers throughout the compaction formula procedure and alertness. Compaction of powder elements either lively factor and excipients is tested to make sure constant and reproducible disintegration and dispersion profiles. This particular reference covers: the actual constitution of pharmaceutical compacts bonding phenomena that ensue in the course of powder compaction compression mechanisms of pharmaceutical debris theories and uncomplicated rules of powder compaction New issues comprise: compaction info research innovations the migration of powder materials into advertisement manufacture instrumentation for compaction compaction performance trying out, that is prone to turn into a USP requirement layout house for compaction metrics required for scalability in capsule compression interactive compaction and preformulation database for general excipients''--Provided via publisher. Read more...
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Additional info for Pharmaceutical powder compaction technology
Tensile strength or deformation hardness). For the production of such tablets the compressional stress sc needs to be important enough to induce plastic flow and/or brittle fracture of the primary granules or particles, that is, to produce simultaneously new surfaces and bonds in this dense powder compact. Process of Uniaxial Compression The usual tabletting machines work according to the principle of uniaxial compression. Thus the upper and lower surface areas of the tablet remain constant during the compression process; the thickness of the tablet is reduced with application of the compressional stress sz in the z-direction.
In attempting to apply a Maxwell rheological form directly to the entire compact, viscoplastic deformation was assumed. The subsequent decomposition of the creep compliance curve as interpreted by the authors has several contradictions. While the reciprocal slope of the compliance curve for a Maxwell fluid should provide an apparent viscosity, the shape of the experimental curve is clearly parabolic. The assumption of a Maxwell form is inappropriate; a higher order rheological model would be more suited to the curvature of the observed data.
J Eng Mater Technol 1992; 114(January):105–110. 31. Swinkels FB, Wilkinson DS, Artz E, et al. Mechanisms of hot-isostatic pressing. Acta Metall 1983; 31(11):1829–1840. 32. Lu GG, Shi X. Computer simulation of isostatic powder compaction by random packing of monosized particles. J Mater Sci Lett 1994; 13:1709–1711. 33. Nolan GT, Kavanagh PE. Random packing of nonspherical particles. Powder Technol 1995; 84: 199–205. 34. Yen KZY, Chaki TK. A computer simulation of rearrangement and compaction of particles under various internal and external stresses.