By Emil W. Ciurczak
This ebook discusses the idea, instrumentation, validation, and implementation of near-infrared spectroscopy for pharmaceutical and clinical functions. It showcases a various diversity of latest tools for the creation, screening, and research of recent drug items and prescription drugs. offers present techniques in near-infrared spectroscopy (NIR) to watch and keep an eye on a number of levels of the drug production approach
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Extra info for Pharmaceutical and Medical Applications of Near-Infrared Spectroscopy
A. Burns and E. W. , Marcel Dekker, New York, 1992, pp. 181–224. 4. E. W. Ciurczak, ‘‘A New In-Line Infrared Sensor,’’ Spectroscopy, 16(1), 16 (2001). Copyright 2002 by Marcel Dekker, Inc. All Rights Reserved 3 Blend Uniformity Analysis I. MIXING Mixing is a basic pharmaceutical processing operation required for the production of most pharmaceutical products. Liquid, solid, or semisolid products are mixed in a large variety of mixers, blenders, and milling machines. The ultimate goal of any mixing process is to achieve content uniformity, a situation where the contents of a mixture are uniformly distributed.
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Shah and Mlodozeniec , in their study of surface lubrication phenomena, suggested that during the mixing process, lubricant particles such as magnesium stearate ﬁrst adsorb onto the surface of individual powder particles or granules, then as mixing continues distribute more uniformly upon the granule surface following delamination or deagglomeration mechanisms. By affecting the surface characteristics of the powder particles, the magnesium stearate may alter the ﬂow properties of the material and affect the apparent bulk volume of the blended material.