By Katherine Rogers
This ebook is designed as a revision and learn reduction for pupil nurses venture their pharmacology module/s and comparable examination evaluate. it's a self-test ebook of self-assessment questions and quizzes that's designed to either try scholars studying and aid them take on their wisdom gaps by way of explaining the solutions to all of the questions integrated. The textual content is organised into physique platforms chapters and every chapter Read more...
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Drugs with low renal clearance rates rely on other elimination mechanisms, usually by the liver in the bile. Doses of drugs with low renal clearance need not be modified for patients with kidney disease. The renal clearance rate in newborn babies and older adults is significantly lower and these patients need to receive lower drug doses (see Chapter 12). 22 The time taken for the concentration of a drug to fall to half its original level is called: a) half-life b) steady state c) elimination d) clearance The half-life (or elimination half-life) of a drug is the time taken for the plasma concentration of a drug to decrease by half.
It usually means a patient requires fewer tablets (if the drug is in tablet form) and side-effects may be reduced because peak plasma levels of the drug are reduced. 86] at [07/18/16]. Copyright © McGraw-Hill Global Education Holdings, LLC. Not to be redistributed or modified in any way without permission. 86] at [07/18/16]. Copyright © McGraw-Hill Global Education Holdings, LLC. Not to be redistributed or modified in any way without permission. indb 22 INTRODUCTION The body has developed very efficient mechanisms to protect itself from infection by invading pathogens.
Many drugs act by targeting natural enzymes and inhibiting their activity. For example, angiotensin converting enzyme (ACE) inhibitor drugs reduce blood pressure by preventing the action of angiotensin converting enzyme which converts angiotensin I to angiotensin II. In the absence of angiotensin II, blood pressure falls. Carrier proteins (or transport systems) may be targeted by drugs to prevent the normal physiological recycling of certain chemical transmitters. An example is the inhibition of the re-uptake of the neurotransmitter serotonin by certain antidepressant drugs, causing an accumulation of serotonin at the synapse, which enhances mood.