Liver Diseases in Infancy and Childhood by Irwin M. Arias M.D. (auth.), Samuel R. Berenberg M.D. (eds.)

By Irwin M. Arias M.D. (auth.), Samuel R. Berenberg M.D. (eds.)

For nearly 4 a long time the Josiah Macy, Jr. origin has been con­ vening meetings in terms of medication, clinical schooling, and healthiness care of their broadest contexts. throughout the Nineteen Forties and Nineteen Fifties the meetings serious about biomedical examine, which was once at the moment in its golden age within the usa. As remedy and scientific schooling ascended in significance, because the mid-1960s the meetings were mostly con­ centrated on subject matters in those fields. The Macy beginning additionally fosters foreign meetings, and a huge attempt lately has been a lucrative collaboration with France's such a lot distinctive scientific statesman, Professor Robert Debre, and the Inter­ nationwide kid's Centre in Paris, which he based and directs. Nineteen seventy-five was once a particularly busy 12 months for this Franco-American alliance: in April there has been a seminar on 'The relatives health care provider: France and the United States'; and, in June, a convention on 'Diseases of the Liver in Infancy and Childhood'. prior Franco-American meetings were on 'Brain improvement' (1972) and on 'Puberty' (1974). As with the others the members during this convention on Liver ailment in Infancy and youth have been drawn from the us and Europe. We have been specifically happy to have as 3 of the members males who carry sabbatical awards as Macy origin college students, Ivan Dia­ mond, M.D., Ph.D., Thomas Starzl, M.D., Ph.D. and M. Michael Thaler, M.D.

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07 1. Expressed as millimicromoles of bilirubin produced per minute per 10 mg protein ± standard deviation. within 3 hrs after being allowed to feed. 05). Prenatal and postnatal fasting had no effect on splenic HO, suggesting that the liver was primarily responsible Table 2. Effect of starvation on GT activity in normal newborn and adult rats. S. S. s. NEONATAL HYPERBILIRUBINEMIA 31 for homeostatic adjustments in bilirubin-forming capacity during fasting. In marked contrast with the influence of fasting on HO activity, GT activity was strikingly reduced in newborn rats fasted for 24 hrs.

J. O'Sullivan, Albumin titratable bilirubin. Bilirubin Meeting, Hemsedalen, Norway, September 1974, 75a-82a. 26. Odell, G. , The dissociation of bilirubin from albumin and its clinical implications. J. Pediat. 55: 268-279 (1959). 27. Odell, G. , S. N. Cohen and P. C. Kelly, Studies in kernicterus. II. The determination of the saturation of serum albumin with bilirubin. J. Pediat. 74: 214-230 (1969). 28. Odell, G. , G. N. B. Storey and L. A. Rosenberg, The saturation of serum proteins with bilirubin during neonatal life and its relationship to brain damage at 5 years.

Sharp, H. , R. A. Bridges, W. Krivit and E. F. Freier, Cirrhosis associated with alpha-I-antitrypsin deficiency: A previously unrecognized inherited disorder. J. Lab. clin. Med. 73: 934-939 (1969). 6. , Mass-screening for ()(l-antitrypsin deficiency: Liver disease during the first 6 months of life. New Engl. J. Med. 1976 (in press). PATHOLOGIC LIVER CHANGES IN ALPHA-I-ANTITRYPSIN DEFICIENT INFANTS (Pi ZZ PHENOTYPE) M. HADCHOUEL AND MARTHE GAUTIER Since the first report of Freier, Sharp and Bridge in 1968, many authors have stressed the association of alpha-I-antitrypsin deficiency and liver disease in children.

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