By Peter Timmins, Samuel R. Pygall, Colin D. Melia
This targeted quantity addresses key matters and sophisticated nuances excited by constructing hydrophilic matrix capsules as an method of oral managed liberate. It brings jointly details from greater than 5 a long time of study and improvement on hydrophilic matrix drugs and gives standpoint on modern concerns. Twelve finished chapters discover numerous subject matters together with polymers (hypromellose, typical polysaccharides and polyethylene oxide) and their usage in hydrophilic matrices, serious interactions impacting pill functionality, in vitro actual and imaging concepts, and microenvironmental pH keep an eye on and combined polymer methods, between others. in a single collective quantity, Hydrophilic Matrix drugs for Oral managed Release presents a unmarried resource of present wisdom, together with sections of formerly unpublished facts. it's an incredible source for business and educational scientists investigating and constructing those oral managed unlock formulations.
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Additional resources for Hydrophilic Matrix Tablets for Oral Controlled Release
Example text
Lower HPMC:drug ratios (<1:1) can lead to attrition, a positive deviation from root time release profiles and burst release if tablet disintegration occurs[17–21]. The polymer:drug ratio also affects the tortuosity of the gel, and it is likely that formation of a strong gel layer occurs in matrices with high polymer contents. At lower HPMC contents, the gel layer may not form as rapidly and gel strength may be lower. Xu and Sunada [66] have postulated that the diffusion layer becomes stronger and more resistant to diffusion and erosion as the HPMC content is increased.
A wide range of drug release profiles can be obtained by changing the HPMC:resin ratio [96]. The type of resin used is important. It has been found, for example, that Dowex 2X-8 provided a greater reduction in the release rate of penicillin V than Amberlite IRA 410, and that the weakly basic ionic exchange resin Amberlite IRA 47 was more effective at retarding sodium salicylate than the strongly basic anionic exchanger Dowex 2X-8, because of its greater exchange capacity [96]. The counterions associated with the resins are also important.
This is presumably because, under these circumstances, the matrix is loose, tends to disintegrate and demonstrates greater channel formation [21, 29, 81]. 3). Dissolution profiles when presented on a root time basis are sigmoidal and they often exhibit an initial non-linear region from 2 to 4 h which is probably due to poor wetting [22, 69]. In addition, because erosion is the dominant mechanism, the many factors described above that influence gel strength can also affect the drug release. HPMC viscosity grade also becomes an important factor because higher viscosity grades have higher gel strengths [69].