By Stanley M. Lemon (auth.), Kiwamu Okita M.D., Ph.D. (eds.)
More than 2 million humans in Japan have persistent hepatitis C and plenty of of them will lose their lives to liver cirrhosis or issues of hepatocellular carcinoma. Hepatitis C virus-related ailments are a major hindrance either in constructing nations and in Japan and the U.S., the place the variety of sufferers can be within the thousands. healing modalities lately constructed in Japan, together with interferon remedy and dietary supportive remedy, are gaining around the world reputation. At this serious juncture, HCV and comparable Liver Diseases offers new info on etiology, pathology, prognosis, and treatment. Viral hepatitis was once the subject matter of the Yamaguchi Symposium on Liver sickness, assembly in December 1998 and attended via top hepatologists and virologists. accumulated during this quantity are the papers from the symposium, delivering a precious source for hepatologists, gastroenterologists, and others operating to appreciate and deal with viral hepatitis.
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Davis GL, Balart LA, SchiffER, Lindsay K, Bodenheimer HC. Ir, Perillo RP, Carey W, Jacobson 1M, Payne I, Dienstag IL, VanThiel DH, Tamburro C, Lefkowitch I, Albrecht I, Meschievitz C, Ortego TJ, Gibas A, Hepatitis Interventional Therapy Group (1989) Treatment of chronic hepatitis C with recombinant interferon alfa: A multicenter randomized, controlled trial. N Engl J Med 321:1501-1506 57. Di Bisceglie AM, Martin P, Kassianides C, Lisker-Melman M, Murray L, Waggoner J, Goodman Z, Banks SM, Hoofnagle IH (1989) Recombinant interferon alfa therapy for chronic hepatitis C: a randomized, double-blind, placebo-controlled trial.
Although this quasispecies nature ofHCV is generated by the limited fidelity of RNA replication, host immunity, especially the humoral immune response, is thought to be one of the important driving forces in the sequence variations of the HVR of H CV [9-11]. We therefore compared the complexity of HVR 1 quasispecies of the HCV genome in serum, PBMCs, and liver, to assess the pathogenic implication of HCV infection in PBMCs. Patients and Methods Eight Japanese patients with type C chronic liver disease (5 men and 3 women, aged 27-58 years, with a mean age of 44) who had HCV type Ib RNA were included in this study (Table O.
Blood 83:269-273 Quasispecies of HCV 33 5. Lerat H, Berby F, Trabaud MA, Vidalin 0, Major M, Trepo C, Inchauspe G (1996) Specific detection of hepatitis C virus strand RNA in hematopoietic cells. J Clin Invest 97:845-851 6. Martell M, Esteban J, Ouer J, Genesca J, Weiner A, Esteban R, Guardia J, et al (1992) Hepatitis C virus (HCV) circulates as a population of different but closely related genomes: quasispecies nature of HCV genome distribution. J Virol 66:3225-3229 7. Hijikata M, Kato N, Ootsuyama Y, Nakagawa M, Ohkoshi S, Shimotohno K (1991) Hypervariable region in the putative glycoprotein of hepatitis C virus.