Drug Targeting Technology: Physical, Chemical, Biological by Hans Schreier

By Hans Schreier

Demonstrates how substitution of quite a few ligands can render albumin a flexible concentrating on software for selective drug accumulation in numerous telephone populations of the liver! Considers the efforts in biotechnology and molecular biology to provide clever drug supply units through exploiting organic pathways! Containing over 1100 references to facilitate extra learn, Drug focusing on know-how updates contemporary development in oral and colonic concentrating on know-how utilizing pH- and enzyme-sensitive coating fabrics and novel polymer structures. Suggesting harnessing organic strategies because the final method of the supply or expression of pharmacologically energetic brokers, Drug focusing on know-how is a top-shelf reference for pharmacists, pharmacologists, and pharmaceutical scientists analytical, floor, actual, and colloid chemists and biochemists and upper-level undergraduate and graduate scholars in those disciplines.

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Despite significant success, however, a number of problems are still awaiting pharmaceutically acceptable and therapeutically useful solutions. First, more reliable in vitro and in vivo tests are necessary. Targeted biodegradation must be improved, as well as the enhancement of colonic absorption. , optimal conditions at the targeting site), the search for microbial activators, and the search for suitable absorption enhancers. Furthermore, all materials used should be ecologically and economically acceptable.

A. Salyers, Bacteroides of the human lower intestinal tract, Ann. Rev. Microbiol. 38:293 (1984). 35. W. E. C. Moore, E. P. Cato, and L. V. Holdeman, Anaerobic bacteria of the gastrointestinal flora and their occurrence in clinical infections, J. Infect. Disease 119:641– 649 (1969). 36. W. D. Keidel, Kurzgefaßtes Lehrbuch der Physiologie, Thieme Verlag, Stuttgart, 1979. 37. O. M. Wrong, A. J. Vince, and J. C. Waterlow, The contribution of endogenous urea to faecal ammonia in man, determined by 15N labelling of plasma urea, Clin.

10. H. Yuasa, Y. Kimura, K. Hamamoto, and J. Watanabe, Evaluation of large intestine as an absorption site for colonic drug delivery, Proceed. Intern. Symp. Control. Rel. Bioact. Mater. 23:547–548 (1996). 11. M. Marvola, H. Aito, P. Pohto, A. Kannikoski, S. Nyka¨nen, and P. Kokkonen, Gastrointestinal transit and concomitant absorption of verapamil from a single-unit sustained-release tablet, Drug Dev. Ind. Pharm. 13:1593–1609 (1987). 12. D. E. Bockman, and M. D. Cooper, Pinocytosis by epithelium associated with lymphoid follicles in the bursa of Fabricius, appendix, and Peyer’s patches, Am.

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