![](https://images-na.ssl-images-amazon.com/images/I/516J4o1QxzL._SX353_BO1,204,203,200_.jpg)
By Joachim K. Seydel, Michael Wiese, Raimund Mannhold, Hugo Kubinyi, Gerd Folkers
Barrier, reservoir, objective web site - these are yet a number of the attainable services of organic lipid membranes within the complicated interaction of gear with the organism. an in depth wisdom of lipid membranes and of a number of the modes of drug-membrane interplay is consequently the prerequisite for a greater figuring out of drug motion. a lot of trendy prescription drugs are amphiphilic or catamphiphilic, permitting them to have interaction with organic membranes. an important membrane houses are surveyed and methods to clarify drug-membrane interactions offered, together with computer-aided predictions. results of membrane interplay on drug motion and drug distribution are mentioned, and diverse examples are given. This designated reference quantity builds at the authors' lengthy adventure within the examine of drug-membrane interplay. prompt examining for everybody excited by pharmaceutical study.
Read Online or Download Drug-Membrane Interactions: Analysis, Drug Distribution, Modeling PDF
Best pharmacy books
Handbook of Pharmaceutical Manufacturing Formulations: Semisolids Products
The fourth quantity within the six-volume guide of Pharmaceutical production Formulations, this ebook covers semi-solid medications. It comprises formulations of ointments, creams, gels, and suppositories, from publicly to be had yet extensively dispersed details from FDA New Drug purposes (NDA), patent functions, and different resources of universal and proprietary formulations.
Independent and Supplementary Prescribing: An Essential Guide
Prescribing and drugs administration is without doubt one of the most typical interventions in future health care supply and sooner or later becomes a part of the position of many hundreds of thousands of nurses, pharmacists and different professions allied to drugs (PAMs). self sustaining and Supplementary Prescribing: an important consultant is the 1st booklet of its style and explores a few key components for prescribers, together with the moral and felony concerns surrounding prescribing, the psychology and sociology of prescribing, prescribing inside a public overall healthiness context, evidence-based prescribing, prescribing inside of a group context, simple pharmacology, tracking talents and drug calculations.
Pharmaceutical Dosage Forms: Tablets, Second Edition, --Volume 3
Entire in three volumes. Pharmaceutical expertise. 14 members.
163 pages, fifty four figures
- Essential Management Skills for Pharmacy and Business Managers
- Drug Delivery Strategies for Poorly Water-Soluble Drugs (Advances in Pharmaceutical Technology)
- Controlled Drug Release Of Oral Dosage Forms (Ellis Horwood Books in the Biological Sciences)
- High-yield basic science , 1st Edition
- Translational Medicine: The Future of Therapy?
- Chirality in Drug Research, Volume 33 (Methods and Principles in Medicinal Chemistry)
Extra info for Drug-Membrane Interactions: Analysis, Drug Distribution, Modeling
Sample text
Annu. Rev. Biophys. Bioeng. 1980, 9, 467–508. , Biochim. Biophys. Acta 1967, 135, 624–638. , Methods Membr. Biol. 1974, 1, 1–68. , Proc. Natl. Acad. Sci. A. 1978. 75, 4194–4198. , Biochim. Biophys. Acta 1980, 601, 559–571. , 82 83 84 85 86 87 88 89 90 91 . 92 93 94 95 96 97 98 99 Biochim. Biophys. Acta 1989, 986, 200–206. , Biochim. Biophys. Acta 1991, 1061, 297–303. , J. Med. Chem. 1991, 34, 869–877. , J. Pharm. Sci, 1989, 78, 172–175. , Biochim. Biophys. Acta 1999, 1417, 232–245. , Pharm. Res.
In Gram-positive bacteria, the cell wall is 20–80 nm thick, and consists of 50% peptidoglycan, which is organized in up to 40 layers [52, 53]; in contrast, the bilayer membrane of a mammalian cell is only 10 nm thick. Other essential components are teichon and teichuronic acid, and acidic, water-soluble polymers that are connected by phosphodiester bridges. The large number of phosphate groups results in a strong negative charge on the cell surface which – under physiological conditions – is partially neutralized by alanyl residues and possibly by Mg2+ ions.
J. Med. Microbiol. 2000, 290, 251–258. , in Advances in Microbial Physiolgy, Vol. H. Rose, J. ), Academic Press, London 1979, pp. 163–250. D. Science 1966, 153, 1491–1498. , Science 1994, 264, 382–388. , in Chemistry of Endotoxin, Vol. Th. ), Elsevier Science, Amsterdam 1984, pp. 17–23. , in Pathophysiology of Endotoxin, Handbook of Endotoxin Vol. B. ), Elsevier Science, Amsterdam 1985, pp. 1–15. , in Chemistry of Endotoxin, Handbook of Endotoxin Vol. Th. ), Elsevier Science, Amsterdam 1984, pp.