By Joachim K. Seydel, Michael Wiese, Raimund Mannhold, Hugo Kubinyi, Gerd Folkers
Barrier, reservoir, objective web site - these are yet a number of the attainable services of organic lipid membranes within the complicated interaction of gear with the organism. an in depth wisdom of lipid membranes and of a number of the modes of drug-membrane interplay is consequently the prerequisite for a greater figuring out of drug motion. a lot of trendy prescription drugs are amphiphilic or catamphiphilic, permitting them to have interaction with organic membranes. an important membrane houses are surveyed and methods to clarify drug-membrane interactions offered, together with computer-aided predictions. results of membrane interplay on drug motion and drug distribution are mentioned, and diverse examples are given. This designated reference quantity builds at the authors' lengthy adventure within the examine of drug-membrane interplay. prompt examining for everybody excited by pharmaceutical study.
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Extra info for Drug-Membrane Interactions: Analysis, Drug Distribution, Modeling
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In Gram-positive bacteria, the cell wall is 20–80 nm thick, and consists of 50% peptidoglycan, which is organized in up to 40 layers [52, 53]; in contrast, the bilayer membrane of a mammalian cell is only 10 nm thick. Other essential components are teichon and teichuronic acid, and acidic, water-soluble polymers that are connected by phosphodiester bridges. The large number of phosphate groups results in a strong negative charge on the cell surface which – under physiological conditions – is partially neutralized by alanyl residues and possibly by Mg2+ ions.
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