British National Formulary 61 by Bma

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Sample text

Absence of information does not imply safety. It should be noted that the BNF provides independent advice and may not always agree with the product literature. Information on drugs and pregnancy is also available from the UK Teratology Information Service. org During the first trimester drugs can produce congenital malformations (teratogenesis), and the period of greatest risk is from the third to the eleventh week of pregnancy. 20 Prescribing in palliative care BNF 61 Prescribing in palliative care Prescribing in palliative care Palliative care is the active total care of patients whose disease is not responsive to curative treatment.

Occasionally a rare side-effect might be listed first if it is considered to be particularly important because of its seriousness. 13 14 Adverse reactions to drugs Teeth and Jaw Adverse reactions to drugs Brown staining of the teeth frequently follows the use of chlorhexidine mouthwash, spray or gel, but can readily be removed by polishing. Iron salts in liquid form can stain the enamel black. Superficial staining has been reported rarely with co-amoxiclav suspension. Intrinsic staining of the teeth is most commonly caused by tetracyclines.

Some flexibility should be allowed in children to avoid waking them during the night. For example, the night-time dose may be given at the child’s bedtime. Where new or potentially toxic drugs are used, the manufacturers’ recommended doses should be carefully followed. BNF 61 BNF 61 Prescribing in hepatic impairment 17 Prescribing in hepatic impairment Liver disease may alter the response to drugs in several ways as indicated below, and drug prescribing should be kept to a minimum in all patients with severe liver disease.

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