Drug Development: Molecular Targets for GI Diseases by John L. Wallace (auth.), Timothy S. Gaginella, Antonio

By John L. Wallace (auth.), Timothy S. Gaginella, Antonio Guglietta (eds.)

Drug improvement: Molecular goals for Gastrointestinal disorder brings jointly a panel of extraordinary specialists to seriously overview the various promising new components of gastrointestinal pharmacology on the molecular point. Key chapters talk about such significant topics because the cyclooxygenase-2 inhibitors, the complexities of nitric oxide pathways within the intestine, and the impression of cytokines on inflammatory bowel affliction, in addition to new possibilities for pharmacotherapy, together with peptide development elements, tachykinins-particularly substance P and neurokinins-cholecystokinin receptors, and serotonin. additionally tested as attainable websites for treating motility problems and visceral soreness are the opioid receptors living within the intestine, and the H3-receptor agonists for treating intestine irritation and soreness. Drug improvement: Molecular objectives for Gastrointestinal affliction presents a accomplished assessment of contemporary molecular pharmacological methods to the invention and improvement of novel medications for gastrointestinal and liver illnesses. Its vast references, richly skilled members, and state-of-the-art syntheses of previous, current, and emergent examine identify the ebook as an important source for all pharmacologists, medicinal chemists, and clinicians looking extra robust medicines for the prevention and therapy of gastrointestinal problems.

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1997a). However, their potency, selectivity, and profile of actions indicate that caution must exercised with the use of these agents. Thus, aminoguanidine has been shown to effectively inhibit eNOS, as well as iNOS in vivo, in a number of preparations (Laszlo and Whittle, 1997). , 1997). L-Iysine, an inhibitor of L-arginine uptake, has been shown to exert beneficial hemodynamic effects, and to reduce organ dysfunction in endotoxic shock. , 1997b). However, since this essential amina acid will have other biochemical functions, its use as a therapeutic agent will be limited.

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Transdermal nitroglycerin prevents nonsteroidal antiinflammatory drug gastropathy. Eur J Pharmacol1995; 281: R3-R4. Barrachina MD, Calatayud S, Esplugues J, Whittle BJR, Moncada S, Esplugues JV. Nitric oxide donors preferentially inhibit neuronally-mediated rat gastric acid secretion. Eur J Pharmacol1994; 262: 181-183. Chapter 2 / NO Pathway in GI Disease 45 Barry MK, Aloisi JD, Pickering SP, Yeo CJ. Nitric oxide modulates water and electrolyte transport in the ileum. Ann Surg 1994; 219: 382-388.

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