Applications of Microdialysis in Pharmaceutical Science by Tung-Hu Tsai

By Tung-Hu Tsai

Discover new and rising functions for microdialysis in drug evaluation

Microdialysis is a hugely necessary sampling software that may be utilized in vivo to degree loose, unbound analyte concentrations situated in interstitial and extracellular areas. This publication explores the complete diversity of medical purposes for microdialysis, concentrating on its use in numerous organ and tissue platforms for pharmacokinetic and pharmacodynamic reviews. Readers achieve a whole knowing of the underlying technological know-how of microdialysis, present options and practices, in addition to its many functions in pharmaceutical research.

Applications of Microdialysis in Pharmaceutical technological know-how begins with an advent to easy rules after which covers analytical concerns, pharmacodynamic and pharmacokinetic experiences, scientific points, and certain purposes. subject matters include:

  • Role of microdialysis in drug improvement, together with an important sampling issues and purposes for apprehensive procedure diseases

  • Continuous size of glucose concentrations in diabetics

  • Applications for medical overview and uncomplicated learn on organ platforms, together with tracking exogenous and endogenous compounds within the lungs

  • Pharmacokinetic and pharmacodynamic overview of anticancer drugs

  • Comparison of microdialysis with imaging methods to judge in vivo drug distribution

  • Special functions of microdialysis in reviews of mobile tradition assays, drug-drug interactions, and environmental monitoring

Throughout the ebook, readers will locate basic versions that make clear complicated strategies and easy-to-follow examples that advisor them via key functions in pharmaceutical learn. in brief, this publication allows pharmaceutical researchers to take complete benefit of microdialysis options for the preclinical and scientific evaluate of gear and lots more and plenty extra.

Show description

Read or Download Applications of Microdialysis in Pharmaceutical Science PDF

Best pharmacy books

Handbook of Pharmaceutical Manufacturing Formulations: Semisolids Products

The fourth quantity within the six-volume guide of Pharmaceutical production Formulations, this booklet covers semi-solid medicines. It comprises formulations of ointments, creams, gels, and suppositories, from publicly to be had yet generally dispersed info from FDA New Drug purposes (NDA), patent functions, and different resources of normal and proprietary formulations.

Independent and Supplementary Prescribing: An Essential Guide

Prescribing and drugs administration is without doubt one of the most typical interventions in well-being care supply and sooner or later becomes a part of the position of many hundreds of thousands of nurses, pharmacists and different professions allied to medication (PAMs). self sustaining and Supplementary Prescribing: a vital consultant is the 1st e-book of its style and explores a few key components for prescribers, together with the moral and felony matters surrounding prescribing, the psychology and sociology of prescribing, prescribing inside of a public well-being context, evidence-based prescribing, prescribing inside a workforce context, easy pharmacology, tracking talents and drug calculations.

Pharmaceutical Dosage Forms: Tablets, Second Edition, --Volume 3

Whole in three volumes. Pharmaceutical know-how. 14 members.

The Alkaloids of Ergot

163 pages, fifty four figures

Additional resources for Applications of Microdialysis in Pharmaceutical Science

Sample text

These probes are composed of stainless steel and are implanted into the specific region of interest using a guide cannula. indd 41 7/11/2011 12:15:06 PM 42 ANALYTICAL CONSIDERATIONS FOR MICRODIALYSIS SAMPLING 15 mm long, with an outer diameter between 200 and 500 μm. The dialysis membrane is located at the end of the concentric cannula and is usually 1 to 4 mm in length. Smaller probes are also available for sampling in mice. The mouse probes employ shorter shafts (7 to 12 mm) and have outer diameters between 220 and 380 μm.

Nature Reviews: Neuroscience, 6, 591–602. N. (2009). Vigabatrin extracellular pharmacokinetics and concurrent gamma-aminobutyric acid neurotransmitter effects in rat frontal cortex and hippocampus using microdialysis. Epilepsia, 50, 174–183. , Girardi, E. (2007). Nimodipine restores the altered hippocampal phenytoin pharmacokinetics in a refractory epileptic model. Neuroscience Letters, 413, 168–172. [56] Physician’s Desk Reference (2006). Zonegran clinical pharmacology FDAapproved label. IndexSearchTranslator.

93] Müller Reporting Company, Inc. Anti-infective drugs advisory committee meeting, 64th meeting. Department of Health and Human Services, Food and Drug Administration. Guidance documents on developing antimicrobial drugs: general considerations and individual indications. pdf. Accessed November 2008. [94] European Medicines Agency (2007). Guideline on the investigation of medicinal products in the term and preterm neonate. pdf. Accessed November 2008. [95] European Medicines Agency (2006). Guideline on the non-clinical investigation of the dependence potential of medicinal products.

Download PDF sample

Rated 4.29 of 5 – based on 46 votes