Annual Reports in Medicinal Chemistry, 4 by C K Cain

By C K Cain


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V. 54 H XVII Chap. 5 Antihypertensives Robinson 53 - A chemically unique l y s e r g i c a c i d congener ( X V , PIA) produced s u s t a i n e d lowering50f blood p r e s s u r e i n hypertensive dogs and normotensive c a t s . The mechanism appeared t o be ablockade which was more e a s i l y r e v e r s i b l e than that of dibenamine. Compound X V I was found t o be a s t r o n g a d r e n o l y t i c devoid of oxytocic activity26 S e v e r a l papers r e p o r t e d t h e c l i n i c a l a n t i h y p e r t e n s i v e e f f i c a c y of a combination of d i h y d r o e r g o c r i s t i n e , clopamide, and r e s e r p i n e .

1 T h i s i n c l u d e s work frori over 40 c o n t r i b u t o r s on t h e i a b o r a t o r y and c l i n i c a l e v a l u a t i o n of a n n l p e s i c s with reviews ci” c u r r e n t l y favored c o n c e p t s of t h e riechanism of t h e p e r c e p t i o n of p 2 i n and i t s blockade. 2 r e v i e w , 3 ] i n p r e s e n t s t h a t r e c e n t work which h a s been r e p o r t e d on t h e s i t e of a c t i o n of a n a l g e s i c s and. t h e n a t u r e of t h e p a i n receptors I -jtronf; .

A. J. , 2, 219(1968). S. L. , 2,711(1968). 74. K. Opitz and U. , %3,318(1968). 75. J. R. Bianchine and L. Exp. , 161,130(1968). 76. P. J. E. , 13,41(1968). 77. H. Helfer and R. Acta, &,137(1968). 78. H. S. B. Dayton,Proc. Exp. Med. , 118, 763( 1965). ~ - - 79. J. D. S. , 160, 217( 1968). 80. J. C. A. Johnson and C. J. Pharmacol. , 2,295(1968). 81. M. Smith, E. H. K. Pharrnaco1. Therap,, *,468(1968). 82. P. Burn. , 34,251(1968). 83. H. , 18,919(1968). S e c t i o n I1 - Pharmacodynamic a g e n t s Barry M.

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