By Chester S. Ho (Eds.)
Animal mobilephone tradition is chargeable for a number medically vital items, reminiscent of vaccines, antibodies, hormones, cytokines, development elements and enzymes. As those items are advancing towards commercialization, the biotechnology has quickly elevated the skill requirement for large-scale ''in vitro'' construction of animal cells and their items. This publication makes a speciality of the underlying ideas and techniques at the back of ''in vitro'' mobile cultures
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Extra info for Animal Cell Bioreactors
Example text
1) was correlated with a decreased intercellular a d h e s i o n (Brackenburry et al. 1984). , they are able to grow either a t t a c h e d or in suspension. W h e n a t t a c h e d they grow in multiple layers b e y o n d the confluent m o n o l a y e r stage. T h i s is particularly a p p a r e n t for those lines capable of m o d e r a t e a t t a c h m e n t to s u p p o r t s like microcarriers, as observed for s o m e genetically engineered fibroblast cultures. Since the t r a n s f o r m a t i o n is a m u l t i s t e p process (Quintanilla et al.
U n d e r such a situation cells m a y initially grow vigorously a n d cease to d o so w h e n they reach a high density. Similarly, a n c h o r a g e - d e p e n d e n t cells m a y grow vigorously before reaching a confluency o n a s u p p o r t (be it m i crocarrier or highly m a c r o p o r o u s matrix). At this point, proliferation is considerably reduced a n d a culture will reach a m a i n t e n a n c e status, p r o vided a c o n v e n i e n t m e d i a switch is p r o v i d e d (from s e r u m to serum-free media).
M a y alter the signal processing a n d consequently the cell-binding strength a n d cell shape. 2 Cell-Substratum (Extracellular Matrix) Interaction O t h e r m o r p h o r e g u l a t o r y insoluble molecules i n v o l v e d in signaling between cell a n d s u b s t r a t u m are substrate a d h e s i o n molecules (SAMs), their receptors o n respective cells, focal contact molecules ( F C M s ) , a n d cell j u n c t i o n molecules (CJMs). T h e a d h e s i o n with a s u b s t r a t u m via S A M s involves interaction between cell-surface receptors a n d o n e or m o r e extracellular molecules.