Thyroid Diseases in Childhood: Recent Advances from Basic by Gianni Bona, Filippo De Luca, Alice Monzani

By Gianni Bona, Filippo De Luca, Alice Monzani

This booklet covers the complete spectrum of thyroid illnesses in early life, targeting the new advances which were completed, from development in easy technological know-how examine via to novel or better methods to analysis and therapy. Introductory chapters talk about thyroid embryogenesis and the function of thyroid hormones in fetal improvement. the 2 contrasting types of thyroid disorder, hypo- and hyperthyroidism, are then thought of intensive, with specific realization to the molecular explanations of congenital hypothyroidism. one of the different themes addressed are autoimmune thyroiditis, thyroid nodules, and pediatric neoplasms. The ebook concludes with an outline of promising healing ways, resembling stem telephone treatment. each one subject is taken care of via an eminent professional within the box, making sure continuously top of the range. Thyroid ailments in formative years could be a big resource of data for endocrinologists, pediatricians, oncologists, and gynecologists, in addition to different execs drawn to this topic.

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Extra resources for Thyroid Diseases in Childhood: Recent Advances from Basic Science to Clinical Practice

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Immunochemical methods can be classified in “competitive” and “noncompetitive” methods. In a competitive immunoassay, all reactants are mixed together, simultaneously or sequentially with different sensitivity. In a noncompetitive 5 Laboratory Aspects in Neonatal Screening of Congenital Hypothyroidism 47 immunoassay, a capture antibody is adsorbed or covalently bound to a surface of a solid phase. The antigen to measure reacts with the solid-phase capture antibody. After a washing action to remove other proteins, a labeled antibody is added and reacts with the bound antigen through a second distinct epitope: after a new washing action, the bound label is determined, and its concentration or activity is directly proportional to the concentration of the antigen.

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