By L. Fundukian
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Extra info for The Gale Encyclopedia of Genetic Disorders
18 G AL E E N CY CL O PE DI A O F G EN E TI C D IS OR D E RS 3 If I take Accutane in the future, how long before conception should I stop taking the drug? What are the risks if my baby has heart surgery? How severe is my child’s hearing loss? At what age can my baby’s hearing be accurately checked? Prognosis Accutane is a safe and highly effective drug when used properly. However, Accutane embryopathy is a serious medical condition that is directly related to a mother’s use of Accutane during the first trimester of her pregnancy.
In 1988, Roche developed the Accutane Pregnancy Prevention Program (PPP). It was fully implemented in mid-1989. The goal of the PPP was to develop educational materials about Accutane for both patients and their doctors. A PPP kit included a consent form and a patient information brochure. Prescribing physicians were encouraged to obtain informed consent from all of their patients after a verbal discussion of the risks and benefits of the drug. Pregnancy tests were strongly encouraged prior to beginning treatment.
Aneuploidy, or an abnormal number of chromosomes, has been seen in several acardiac twins, but is rare in the normal twins. Trisomy 2, the presence of three copies of human chromosome 2 instead of the normal two copies, has been reported in the abnormal twin of two pregnancies complicated by TRAP sequence in different women. For both of these pregnancies the pump twin had normal chromosome numbers. Since monozygotic twins are formed from a single zygote, scientists theorize that an error occurs early in cell division in only one of the two groups of cells formed during this process.