Review of Organic Functional Groups: Introduction to by Thomas L. Lemke PhD, Victoria F. Roche PhD, S. William Zito

By Thomas L. Lemke PhD, Victoria F. Roche PhD, S. William Zito PhD

With its scholar Workbook CD-ROM and new case stories, the 5th version of this acclaimed self-paced evaluation helps you to grasp the foundations and purposes of natural practical teams. in addition, it prepares you for the mandatory pharmacy classes in medicinal chemistry by means of completely overlaying nomenclature, actual homes, chemical houses, and metabolism. As you move in the course of the textual content, you will improve such vital abilities as drawing chemical buildings and predicting the solubility, instabilities, and metabolism of every natural sensible team.

Show description

Read Online or Download Review of Organic Functional Groups: Introduction to Medicinal Organic Chemistry PDF

Best pharmacy books

Handbook of Pharmaceutical Manufacturing Formulations: Semisolids Products

The fourth quantity within the six-volume guide of Pharmaceutical production Formulations, this ebook covers semi-solid medicines. It contains formulations of ointments, creams, gels, and suppositories, from publicly to be had yet largely dispersed info from FDA New Drug purposes (NDA), patent purposes, and different assets of regular and proprietary formulations.

Independent and Supplementary Prescribing: An Essential Guide

Prescribing and drugs administration is among the commonest interventions in healthiness care supply and sooner or later becomes a part of the function of many millions of nurses, pharmacists and different professions allied to medication (PAMs). autonomous and Supplementary Prescribing: an important consultant is the 1st ebook of its style and explores a few key parts for prescribers, together with the moral and felony matters surrounding prescribing, the psychology and sociology of prescribing, prescribing inside a public well-being context, evidence-based prescribing, prescribing inside a workforce context, simple pharmacology, tracking talents and drug calculations.

Pharmaceutical Dosage Forms: Tablets, Second Edition, --Volume 3

Entire in three volumes. Pharmaceutical expertise. 14 individuals.

The Alkaloids of Ergot

163 pages, fifty four figures

Extra info for Review of Organic Functional Groups: Introduction to Medicinal Organic Chemistry

Example text

The metabolism of phenols is much like that of alcohols. The phenol may be oxidized, or, using the terminology previously used for aromatic oxidation, the phenol may be hydroxylated, to give a diphenolic compound (Fig. 7-5) (phase 1 reaction). In most cases, the new OH group will be either ortho or para to the original hydroxyl group. Hydroxylation reactions are commonly catalyzed by members of the cytochrome P450 family of enzymes. The most common form of metabolism of phenols is conjugation with glucuronic acid to form the glucuronide or sulfonation to give the sulfate conjugate (phase 2 reaction).

A thiol functional group is readily oxidized by molecular oxygen to a disulfide dimer. An example of such an instability is seen with the (continued) 10166_ch08 28/06/10 12:20 PM Page 40 40 REVIEW OF ORGANIC FUNCTIONAL GROUPS Thiol Oxidation (continued) drug captopril which is oxidized in solution to its dimer. The thiol–disulfide interconversion plays a significant role in the three-dimensional structure of proteins. 1 Opioid analgesics are potent pain relievers that work in the brain and spinal cord (CNS).

Another significant property of phenols is their chemical reactivity. An important reaction is shown in Figure 7-3. Because phenol is a weak acid, it will not react with sodium bicarbonate, a weak base, but will react with strong bases such as sodium hydroxide or potassium hydroxide to give the respective phenolate salts. FIGURE 7-3. Acid-base reaction between phenol and a strong base. Salt formation is an important reaction since the phenolates formed are ions and will dissolve in water through the much stronger ion-dipole bonding.

Download PDF sample

Rated 4.95 of 5 – based on 33 votes