Recent Progress in Alzheimer's and Parkinson's Diseases by Israel Hanin, Ramon Cacabelos, Abraham Fisher

By Israel Hanin, Ramon Cacabelos, Abraham Fisher

This e-book brings jointly the complaints of Alzheimer's and Parkinson's ailments: New views, the 6th foreign convention on Alzheimer's ailment and Parkinson's sickness, held lately in Seville, Spain. Chapters contributed via top experts within the box talk about the most recent advancements within the easy technology and treatment of Alzheimer's and Parkinson's ailments.

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J Am Med Assoc 1999; 281: 341–6 Polymeropoulos MH, Lavedan C, Leroy E, et al. Mutation in the alpha-synuclein gene identified in families with Parkinson’s disease. Science 1997; 276: 2045–7 7 Hanin Ch 1 31/3/05 12:07 pm Page 8 Recent Progress in Alzheimer’s and Parkinson’s Diseases fibrillization, is a shared property of both alpha-synuclein mutations linked to early-onset Parkinson’s disease: implications for pathogenesis and therapy. Proc Natl Acad Sci USA 2000; 97: 571–6 16. Ostrerova-Golts NL, Petrucelli J, Hardy J, et al.

Parkinson’s disease and exposure to rural environmental factors: a population based case–control study. Can J Neurol Sci 1991; 18: 279–86 9. Spillantini M, Schmidt M, Lee VM, et al. αSynuclein in Lewy bodies. Nature 1997; 388: 839–40 10. Spillantini MG, Crowther RA, Jakes R, et al. αSynuclein in filamentous inclusions of Lewy bodies from Parkinson’s disease and dementia with lewy bodies. Proc Natl Acad Sci USA 1998; 95: 6469–73 3. Liou HH, Tsai MC, Chen CJ, et al. Environmental risk factors and Parkinson’s disease: a case–control study in Taiwan.

It is helpful to ask the patient to use a diary and mark in this booklet the intake of medication, on- and off-periods and occurrence of dyskinesia. If this is impossible, short-term observation on the ward may be necessary. Peak-dose dyskinesia occurs normally 60 min after intake of levodopa, and can be diagnosed by levodopa analysis in the blood. In this situation it is mandatory to decrease the dosage of levodopa even if mobility also decreases. Patients will usually be less happy with this, since they prefer to be hyperkinetic than to be hypokinetic, in contrast to their caregivers, who find it difficult to deal with longlasting dyskinesias.

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