By Dimos D. Mitsikostas, Koen Paemeleire
During this ebook, headache specialists summarize all of the presently on hand remedies for fundamental complications and most significantly, describe the ‘tricks’ that could make sure the good fortune of headache pharmacotherapy. Prevention and acute therapy of migraine and cluster headache obtain specific consciousness and person chapters are dedicated to the therapy of basic complications in particular teams, i.e. kids, pregnant girls and the aged. extra chapters concentrate on chosen secondary headache problems and cranial neuralgias for which pharmacotherapy is on the market. The booklet is designed to satisfy the day-by-day perform wishes of basic physicians, normal neurologists, neurologists in education and scientific scholars. Headache is still a number one cause of humans to hunt clinical session, and migraine and different fundamental headache issues are categorized through the WHO as one of the so much disabling health conditions within the common inhabitants, usually affecting participants in the course of their most efficient years. regrettably, less than therapy and mismanagement are the destiny of many headache sufferers and this ebook offers a valid foundation for optimizing remedy.
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Extra resources for Pharmacological Management of Headaches
Example text
Tfelt-Hansen P, Saxena PR, Dahlöf C, Pascual J, Láinez M, Henry P, Diener H, Schoenen J, Ferrari MD, Goadsby PJ (2000) Ergotamine in the acute treatment of migraine: a review and european consensus. Brain 123:9–18 9. Sarchielli P, Granella F, Prudenzano MP, Pini LA, Guidetti V, Bono G, Pinessi L, Alessandri M, Antonaci F, Fanciullacci M, Ferrari A, Guazzelli M, Nappi G, Sances G, Sandrini G, Savi L, Tassorelli C, Zanchin G (2012) Italian guidelines for primary headaches: 2012 revised version. J Headache Pain 13(Suppl 2):S31–S70 10.
In this meta-analysis, all RCTs using any compound, either for acute or for chronic treatment, were included. The aim was to estimate the magnitude of nocebo in headaches in the most clinically relevant manner for both the clinicians and trial designers. 33 %), but in chronic preventive treatments was increased up to 5 %, showing that 1 out of 20 patients treated for migraine prophylaxis discontinues treatment due to nocebo AEs. Practitioners should be aware of this fundamental nocebo effect, trial designers as well [48].
In fact, both ergotamine and dihydroergotamine demonstrate affinities for 5-hydroxytryptamine, dopamine, and noradrenaline receptors since they have a structure similar to these neurotransmitters. 4 Antiemetics Antiemetics, including metoclopramide, prochlorperazine, and chlorpromazine, are effective treatment options for migraine independently from their ability to control nausea and vomiting. They are considered primary options for treating acute migraine in the emergency department setting. They are to be considered adjuvants in the treatment of migraine attacks, especially when nausea or vomiting is prominent: the efficacy of analgesics is reduced in many migraineurs because of impaired gastrointestinal motility, which is associated with nausea, and the nonabsorption of the drugs due to vomiting.