By Rohan Shah, Daniel Eldridge, Enzo Palombo, Ian Harding
What are lipid nanoparticles? How are they established? How are they shaped? What concepts are most sensible to symbolize them? How nice is their power as drug supply platforms? those questions and extra are responded during this entire and hugely readable paintings on lipid nanoparticles. This paintings units out to supply the reader with a transparent and comprehensible realizing of the present practices in formula, characterization and drug supply of lipid nanoparticles. A entire description of the present realizing of synthesis, characterization, balance optimization and drug incorporation of reliable lipid nanoparticles is equipped. Nanoparticles have attracted nice curiosity during the last few a long time with nearly exponential development of their study and alertness. Their small particle measurement and next excessive floor zone lead them to excellent in lots of makes use of, yet really as drug service platforms. Nanoparticles made up of lipids are in particular appealing due to their stronger biocompatibility imparted by way of the lipid. The paintings offers an in depth description of the kinds of lipid nanoparticles on hand (e.g. SLN, NLC, LDC, PLN) and the way they vary from imperfect crystalline to amorphous in constitution. present strategies on the place medicinal drugs are positioned (e.g. within the center, or on the interface) and the way this is often manipulated are mentioned. the various innovations for construction, together with the author’s personal version of microwave heating, are absolutely mentioned. recommendations for measuring arguably crucial features of particle measurement and polydispersity are mentioned, in addition to ideas to degree crystallinity, form and drug means. ultimately, a whole bankruptcy on ideas for measuring balance, either within the absence and presence of substances, is mentioned, besides feedback on find out how to optimize that balance. This paintings appeals to scholars of colloid technological know-how, practitioners of analysis into drug supply and teachers alike.
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Additional resources for Lipid Nanoparticles: Production, Characterization and Stability
Example text
2004; Joscelyne and Trägårdh 2000). Membrane contactors have been applied in the manufacture of precipitates including barium sulphate and calcium carbonate (Chen et al. 2004; Jia et al. 2003). For the preparation of lipid nanoparticles, the lipid melt is initially pressed through the pores of a membrane contactor. The pores in the membrane act as parallel capillaries for introduction of the lipid phase. The passage of the lipid melt allows formation of small droplets into the aqueous phase that flow tangentially to the membrane surface.
Powder Technol 139(2):180–185 Chirio D, Gallarate M, Peira E, Battaglia L, Serpe L, Trotta M (2011) Formulation of curcumin-loaded solid lipid nanoparticles produced by fatty acids coacervation technique. J Microencapsul 28(6):537–548 Cortesi R, Esposito E, Luca G, Nastruzzi C (2002) Production of lipospheres as carriers for bioactive compounds. Biomaterials 23(11):2283–2294 Dingler A, Gohla S (2002) Production of solid lipid nanoparticles (SLN): scaling up feasibilities. J Microencapsul 19(1):11–16 Doktorovova S, Shegokar R, Fernandes L, Martins-Lopes P, Silva A, Müller R et al (2014) Trehalose is not a universal solution for solid lipid nanoparticles freeze-drying.
Drug Dev Ind Pharm 28(3):265 Yasuji T, Takeuchi H, Kawashima Y (2008) Particle design of poorly water-soluble drug substances using supercritical fluid technologies. Adv Drug Deliver Rev 60(3):388–398 Chapter 4 Characterization Abstract Lipid nanoparticles are known to present three features—a solid nature, lipid matrix and colloidal (or smaller) particle size. These features are theorized to impart controlled drug release, biocompatibility and improved drug dissolution to the colloidal carriers.