Hepatitis B Virus in Human Diseases by Yun-Fan Liaw, Fabien Zoulim

By Yun-Fan Liaw, Fabien Zoulim

This textual content presents a complete, state-of-the paintings evaluate of this box, and should function a useful source for college students, clinicians, and researchers with an curiosity in hepatitis B. The ebook reports new facts approximately easy and translational technological know-how together with the viral existence cycle, the immunopathogenesis of virus triggered power hepatitis, the mechanism of virus precipitated liver melanoma, and their strength functions for the scientific administration of sufferers. The medical facets of this continual viral an infection are reviewed intimately with very important chapters at the worldwide epidemiology, the typical historical past of the affliction, co-infections with its satellite tv for pc virus HDV or HIV, and administration of designated sufferer populations. an enormous emphasis is made at the administration of antiviral treatment and the hot foreign instructions for the remedy of hepatitis B. ultimately, the ebook reports the present cutting-edge relating to immunoprophylaxis to avoid the unfold of the virus and its significant medical results. the recent advances and views within the improvement of enhanced antiviral remedies also are discussed.

Hepatitis B Virus in Human Diseases will function a truly resource for college kids, physicians and researchers facing, and attracted to, this not easy power viral an infection. it is going to supply a concise but finished precis of the present prestige of the sphere that might aid advisor sufferer administration and stimulate investigative efforts. All chapters are written through specialists of their fields and comprise the hottest clinical and medical information.

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J Virol. 1986;57(1):229–36. 16. Gerlich WH, Robinson WS. Hepatitis B virus contains protein attached to the 5′ terminus of its complete DNA strand. Cell. 1980;21(3):801–9. 17. Bartenschlager R, Schaller H. The amino-terminal domain of the hepadnaviral P-gene encodes the terminal protein (genome-linked protein) believed to prime reverse transcription. EMBO J. 1988;7(13):4185–92. 18. Heermann KH, Goldmann U, Schwartz W, Seyffarth T, Baumgarten H, Gerlich WH. Large surface proteins of hepatitis B virus containing the pre-s sequence.

Shi L, Li S, Shen F, Li H, Qian S, Lee DH, et al. Characterization of nucleosome positioning in hepadnaviral covalently closed circular DNA minichromosomes. J Virol. 2012;86(18): 10059–69. 98. Belloni L, Pollicino T, De Nicola F, Guerrieri F, Raffa G, Fanciulli M, et al. Nuclear HBx binds the HBV minichromosome and modifies the epigenetic regulation of cccDNA function. Proc Natl Acad Sci U S A. 2009;106(47):19975–9. 99. Belloni L, Allweiss L, Guerrieri F, Pediconi N, Volz T, Pollicino T, et al.

106. Junker-Niepmann M, Bartenschlager R, Schaller H. A short cis-acting sequence is required for hepatitis B virus pregenome encapsidation and sufficient for packaging of foreign RNA. EMBO J. 1990;9(10):3389–96. 107. Hirsch RC, Loeb DD, Pollack JR, Ganem D. Cis-acting sequences required for encapsidation of duck hepatitis B virus pregenomic RNA. J Virol. 1991;65(6):3309–16. 108. Bartenschlager R, Schaller H. Hepadnaviral assembly is initiated by polymerase binding to the encapsidation signal in the viral RNA genome.

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