Hamster Immune Responses in Infectious and Oncologic by R. E. Billingham, J. Wayne Streilein (auth.), J. Wayne

By R. E. Billingham, J. Wayne Streilein (auth.), J. Wayne Streilein, David A. Hart, Joan Stein-Streilein, William R. Duncan, Rupert E. Billingham (eds.)

This quantity includes the written contributions of individuals in a symposium held in Dallas, Texas, June 3-5, 1980, entitled "HAMSTER IMMUNE RESPONSIVENESS AND EXPERIMENTAL types OF INFECTIOUS AND ONCO­ common sense DISEASES". This assembly its predecessor, "Hamster Immune Responses: Experimental versions Linking Immunogenetics, Oncogene­ sis and Viral Immunity" via 3 years. This more moderen assembly was once extra pointed in its concentration and the contributions looked to be extra tightly linked. those conferences are a part of an extend~d attempt by way of experimentalists utilizing the Syrian hamster as an animal version approach to assemble employees in in all probability comparable components for the trade of rules and data. The luck of the symposia derives partially from the clinical excellence of the contributing scientists, and partially from the monetary help of the nationwide Institutes of healthiness throughout the Fogarty overseas middle. The management of the collage of Texas well-being technology heart at Dallas, less than President Charles C. Sprague, additionally donated time, amenities, and fiscal sup­ port. coaching of the manuscripts during this quantity, as camera-ready replica for the writer, was once the diligent and devoted attempt of Ms. Sara Howard. reproduction modifying was once expertly played by way of Ms. Sandra Schulte and proof-reading used to be the accountability of Dr. Patricia Fultz and Ms. Alix Gerboth. despite the fact that, ultimate accountability for any mistakes and omis­ sions within the released quantity is taken by means of the 5 neighborhood editors: J. Wayne Streilein David A. Hart Joan Stein-Streilein William R. Duncan R. E.

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Et al. Mol Immunol 16 (1979) 541. P. Proc Soc Exp BioI Med 106 (1961) 255. H. et al. J Pharmacol Exp Ther 153 (1966) 544. Kulczycki, A. Jr. et al. J BioI Chem 254 (1979) 3194. INDUCTION AND REGULATION OF CONTACT HYPERSENSITIVITY IN SYRIAN HAMSTERS J. Wayne Streilein, Pamela Witte, Kim Burnham and Paul R. Bergstresser Departments of Cell Biology and Internal Medicine The University of Texas Health Science Center at Dallas Dallas, TX 75235 INTRODUCTION Syrian hamsters were introduced into experimental biology more than 50 years ago when it was found that they were particularly useful for the study of certain parasitic diseases (1).

REFERENCES 1. 2. 3. 4. 5. 6. 7. 8. 9. 10. 11. 12. 13. 14. 15. 16. 17. H. Proc R Soc Lond [Biol] 148 (1958) 216. W. Transplantation 25 (1978a) 12. E. J Exp Med 132 (1970) 168. W. J Immunol 118 (1977) 832. Palm, J. et al. J Hered 58 (1967) 40. E. et al. Reconstr Surg Traumatol 34 (1967) 329. W. Transplantation 25 (1978b) 17. Klein, J. Adv Immunol 26 (1978) 55. C. et al. Immunogenetics 3 (1976) 241. H. et al. Immunogenetics 1 (1975) 457. S. Adv Immunol 29 (1975) 125. Klein, J. Science 203 (1979) 516.

These data suggest that this antiserum contains at least two antibodies: one antibody recognizes a specificity shared by UT2, SYR, and MIT; the second antibody recognizes a specificity present only in UT2 and SYR. The new catch of recently-wild Syrian hamsters therefore allows the definition of new histocompatibility determinants, some of which induce T cell proliferation as measured by MLR, while others elicit the production of cytotoxic alloantibodies. To determine whether Table 6. Absorption Analysis of Hamster Alloantisera: Between Recently-Wild Strains Antiserum Absorbed by MHA anti-UT1/UT2 UT2 SYR MIT lCytotoxicity: + o Differences Cytotoxicity with target cells 1 MIT UT2 SYR + o o o + o o + o o + + greater than 90% lysis at a 1:16 dilution of antiserum.

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