Good Pharmaceutical Freeze-Drying Practice by Peter Cameron

By Peter Cameron

This article is dedicated to pharmaceutical freeze-drying in all its types and in all its technological adaptations. no matter if you freeze-dry nonsterile pills otherwise you lyophilize injectables, this ebook covers all of the technological and regulatory necessities. Written by way of a panel of major practitioners within the pharmaceutical -- construction specialists, regulatory inspectors, technical experts, and kit providers -- the data is correct, usable, and well timed. sensible, "how to" chapters function education aids, and every part stands by itself as a concise, easy-to-access source for either managers and technicians.

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Expert Review of Anticancer Therapy 2002, 2, 161-168. 17. Culy, C. R; Faulds, D. Drugs 2002,62,2249-50. 18. Herbst, R. S. Expert Opinion on Investigational Drugs 2002,II, 837-849. 19. Laird, A. ; Chemngton, J. M. Expert Opinion on Investigational Drugs 2003, 12,51-64. 38 Contemporary Drug Synthesiq 20. Gibson, K. H. WO 96/33980 (1996). 21. Barker, A. ; Gibson, K. ; Godfrey, A. ; Barlow, J. ; Healy, M. ; Woodbum, J. ; Ashton, S . ; Curry, B. ; Richards, L. Bioorg. Med. C h m . Left. 2001,11, 1911-1914.

Looking at the structures of 4 versus 41, the only difference is a carboxylic acid versus an alcohol. Therefore, it is reasonable to speculate that the increased polarity of cetirizine (4) may be responsible for lowering the blood-brain barrier penetration. 20x2' CI CI oxidation k O p H 4 41 Fig. 3. Evolution of hydroxyzine (41) to cetirizine (4). In term of pharrnacokinetics, cetirizine (4) is rapidly absorbed, reaching a peak plasma concentration of 257 pg/L within 1 h of administration at a dose of 10 mg in healthy volunteers.

1999,38,631-633. ; Evans, J. ; Ford-Hutchinson, A. ; Gauthier, J. ; O’Neill, G. ; Percival, M. ; Young, R. ; Zamboni, R. Bioorg. Med. Chem. Lett. 1999,9,1773-1778. 6. Penning, T. ; Talley, J. ; Bertenshaw, S. ; Carter, J. ; Collins, P. ; Graneto, M. ; Lee, L. ; Malecha, J. ; Miyahiro, J. ; Rogers, R. ; Rogier, D. ; Yu, S. ; Anderson, G. ; Koboldt, C. ; Perkins, W. ; Veenhuizen, A. ; Zhang, Y. ; Isakson, P. C. J. Med. Chem. 1997, 40,1347-1365. 7. Talley, J. ; Penning, T. ; Collins, P. ; Rogier, D.

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