By Ping I. Lee and William R. Good (Eds.)
content material: evaluate of controlled-release drug supply / Ping I. Lee and William R. reliable --
Microstructural types for diffusive shipping in porous polymers / W. Mark Saltzman, Stephen H. Pasternak, and Robert Langer --
Diffusion in heterogeneous media / Bret Berner, J.C. Keister, and Eugene R. Cooper --
Estimation of premiums of drug diffusion in polymers / C.G. Pitt, A.L. Andrady, Y.T. Bao, and N.K.P. Samuel --
Interpretation of drug-release kinetics from hydrogel matrices by way of time-dependent diffusion coefficients / Ping I. Lee --
Physicochemical versions for percutaneous absorption / J. Hadgraft and Richard H. man --
floor chemical research of polymeric drug supply platforms via static secondary ion mass spectrometry (SSIMS) and SIMS imaging / M.C. Davies and A. Brown --
more desirable process for measuring in vitro diffusion of substances via human pores and skin / L.R. Brown, J.F. Cline, C.L. Raleigh, and M.B. Henry --
Simplified method for measuring controlled-release kinetics / Charles G. Gebelein, Tahseen Mirza, and Robert R. Hartsough --
Thermally reversible gelation features : poly(oxyethylene)-poly(oxypropylene) block copolymer in aqueous resolution after publicity to high-energy irradiation / D. Attwood, C.J. Tait, and J.H. Collett --
unencumber and behind schedule unlock of water-soluble medications from polymer beads with low water swelling / Karl F. Mueller --
Morphine hydrogel suppositories : machine layout, scale-up, and assessment / Marion E. McNeill and Neil B. Graham --
Use of bioerodible polymers in self-regulated drug supply structures / J. Heller, S.H. Pangburn, and D.W.H. Penhale --
Polysaccharides as drug vendors : activation strategies and biodegradation stories / Etienne Schacht, Filip Vandoorne, Joan Vermeersch, and Ruth Duncan --
Microspheres as controlled-release structures for parenteral and nasal management / S.S. Davis, L. Illum, D. Burgess, J. Ratcliffe, and S.N. generators --
improving drug unlock from polylactide microspheres through the use of base within the microencapsulation method / Jones W. Fong, Hawkins V. Maulding, George E. Visscher, Josephine P. Nazareno, and Jane E. Pearson --
results of ethanol at the delivery of [beta]-estradiol in hairless mouse epidermis : comparability of experimental information with a brand new theoretical version / W.I. Higuchi, U.D. Rohr, S.A. Burton, P. Liu, J.L. Fox, A.H. Ghanem, H. Mahmoud, S. Borsadia, and William R. reliable --
Probing the constitution of stratum corneum at the molecular point / ok. Knutson, S.L. Krill, W.J. Lambert, and W.I. Higuchi --
New liposomal supply procedure for managed drug free up / Victoria M. Knepp, Robert S. Hinz, Francis C. Szoka, Jr., and Richard H. man --
more suitable absorption of ionizable medicines from topical dosage kinds / Tsuneji Nagai and Toyoaki Ishikura --
Transdermal drug supply procedure with improved pores and skin permeability / Yei W. Chien and Chia-Shun Lee --
way to increase intranasal peptide supply / Lawrence S. Olanoff and Richard E. Gibson --
Transbuccal absorption of diclofenac sodium in a puppy version / C.D. Ebert, V.A. John, P.T. Beall, and K.A. Rosenzweig --
Constant-release diffusion structures : expense keep watch over via geometric configuration / K.G. Nelson, S.J. Smith, and R.M. Bennett --
Disposable controlled-release equipment for drug infusion / Paul Y. Wang, Mary C.Y. Lee, and will S.M. Smith.
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Extra info for Controlled-Release Technology. Pharmaceutical Applications
J. Med. Chem. 1977, 20, 625-629. 16. ; J. Pharm. Sci. 1976, 65, 1574-1578. 17. ; J. Pharm. Sci. 1973, 62, 210-217. 18. ; Eds. John Wiley and Sons: New York, 1985, pp. 407-432. ; ACS Symposium Series; American Chemical Society: Washington, DC, 1987. Chapter 4 Estimation of Rates of Drug Diffusion in Polymers C. G. Pitt, A. L. Andrady, Y. T. Bao, and Ν. K. P. O. Box 12194, Research Triangle Park, NC 27709 A method of estimating the solubility of drugs in rub bery polymers, based on the octanol-water partition coefficient of the drug, is described.
The a n a l y s i s o f p a r t i c l e s i z e d i s t r i b u t i o n r e q u i r e d an assumption o f p a r t i c l e shape; a l l e n c a p s u l a t e d p a r t i c l e s were assumed t o be e l l i p s o i d s . To v e r i f y t h i s assumption, s i n g l e p a r t i c l e s were r e c o n s t r u c t e d i n t h r e e - d i m e n s i o n s . The r e c o n s t r u c t e d p a r t i c l e s were remarkably s y m m e t r i c a l ; no s i g n i f i c a n t s p u r s o r c o n v e x i t i e s were o b s e r v e d .
Reproduced with permission from Ref. 4. 80/20 METHACRYLATE) M POLYVINYL CHLORIDE) 3 NATURAL RUBBER 19 P O L Y E T H Y L E N E L O 20 P O L Y E T H Y L E N E OXIDE) 13 P0U1NYL CHLORIDE/ACETATE)COP.