Congenital Diseases and the Environment by A. Mantovani, F. Maranghi (auth.), P. Nicolopoulou-Stamati,

By A. Mantovani, F. Maranghi (auth.), P. Nicolopoulou-Stamati, L. Hens, C.V. Howard (eds.)

In contemporary years, expanding consciousness and assets were delivered to endure at the courting among the surroundings and congenital illnesses. those ailments have been formerly regarded as generally because of genetic reasons. although the significance of genes as elements in causation is approved, environmental elements appear to be implicated simply as strongly. This publication explores a few additional suggestions that experience arisen from newer perceptions of environmental results and their attainable interactions with dwelling structures. dialogue and presentation of previous and novel principles is concentrated at constructing a extra holistic and united conception of the interplay among congenital illnesses and the environment.

Amongst the themes mentioned are:

-effects of prenatal publicity to poisonous chemicals

-intra-uterine publicity to medicines

-effects of endocrine disrupters

-environmental hazard and intercourse ratio in newborns

-surveillance of environmental impact

-research and policy

This ebook might be of curiosity to researchers in environmental technology and/or human ecology, overall healthiness execs, NGOs, and the overall public.

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Sample text

O'Malley, C. , Nelson, V. and Jackson, R. J. (1999) Maternal pesticide exposure from multiple sources and selected congenital anomalies, Epidemiology 10, 60-66. Skakkebaek, N. E. (2003) Testicular dysgenesis syndrome, Horm. Res. 60, 49. Steinhardt, G. F. (2004) Endocrine disruption and hypospadias, Adv. Exp. Med. Biol. 545, 203-215. Stoker, T. , Parks, L. , Gray, L. E. and Cooper, R. L. (2000) Endocrine-disrupting chemicals: prepubertal exposures and effects on sexual maturation and thyroid function in the male rat.

And Vrijheid, M. (2003) The impact of environmental pollution on congenital anomalies, Br. Med. Bull. 68, 25-45. , Armstrong, B. G. and Walls, P. H. (1998) Geographical variation in anophthalmia and microphthalmia in England, 1988-94, Br. Med. J. 317, 905-909. P. (1996) Cryptorchidism and delayed testicular descent in Florida black bears. J. Wildl. Dis. 32, 661-664. Dwernychuk, L. W. (2005) Dioxin hot spots in Vietnam, Chemosphere 60, 998-999. INTRODUCTION 15 Dwernychuk, L. , Cau, H. , Hatfield, C.

2004) and exposure to environmental agents, such as toxins, and/or EDs (Newbold, 2005) have been published. Contrary to the traditional tenets of toxicology, toxins have been found to be able to exert subtle effects at concentrations several orders of magnitude lower than those found in classical high dose studies. The fact that these can be altered by individual susceptibility has resulted in the new discipline of pharmacogenomics. An example of this low dose toxicology is provided by Rajapakse et al.

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