
By Hiroyuki Ohshima, Kimiko Makino
Colloid and Interface technology in Pharmaceutical study and Development describes the position of colloid and floor chemistry within the pharmaceutical sciences. It provides a close account of colloid concept, and explains physicochemical houses of the colloidal-pharmaceutical platforms, and the equipment for his or her dimension.
The e-book starts off with basics partly I, protecting basic facets of colloid and interface sciences as utilized to pharmaceutical sciences and therefore could be appropriate for educating. components II and III deal with purposes and measurements, and so they explains the applying of those houses and their impact and use for the improvement of recent medicinal drugs.
- Provides a transparent description of the basics of colloid and interface technological know-how correct to drug learn and development
- Explains the physicochemical/colloidal foundation of pharmaceutical science
- Lists glossy experimental characterization options, offers analytical equations and factors on reading the experimental data
- Describes the main complex concepts, AFM (Atomic strength Microscopy), SFA (Surface strength equipment) in detail
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Extra info for Colloid and interface science in pharmaceutical research and development
Sample text
2 Steric Stabilisation .............................................................. 3 Surface Activity and Colloidal Properties of Drugs ............................................. 4 Naturally Occurring Micelle Forming Systems ................................................... 5 Biological Implications of the Presence of Surfactants in Pharmaceutical Formulations ................................................................................................... 6 Solubilised Systems ........................................................................................
12 (2012) 023001. [14] H. Ohshima, Curr. Opin. Colloid Interface Sci. 18 (2013) 73. [15] R. S. Dukhin, C. L. Duval, Curr. Opin. Colloid Interface Sci. 18 (2013) 83. [16] H. W. R. White, J. Colloid Interface Sci. 90 (1982) 17. [17] H. Ohshima, J. Colloid Interface Sci. 171 (1995) 525. [18] H. Ohshima, J. Colloid Interface Sci. 200 (1998) 291. [19] H. Ohshima, J. Colloid Interface Sci. 174 (1995) 45. V. Derjaguin, Kolloid Z. 69 (1934) 155. J. Sparnaay, Recueil 78 (1959) 680. [22] H. Ohshima, A. Hyono, J.
1 Electrostatic stabilisation In this case a repulsive energy is produced by formation of electrical double layers via adsorption of ionic surfactants. This repulsive energy increases with increase of the surface (or z) potential and decrease of electrolyte concentration. The repulsive energy counteracts the van der Waals attraction at intermediate distance of separation thus producing an energy barrier that prevents flocculation of the dispersion. A summary of the van der Waals attraction and electrostatic repulsion as well as their combination is given below.