Burger's Medicinal Chemistry and Drug Discovery, Drug by Donald J. Abraham

By Donald J. Abraham

This can be quantity 1: Drug Discovery, of Burger's Medicinal Chemistry and Drug Discovery, sixth version. This new quantity comprises severe new chapters on digital Screening, Bioinformatics and Chemical details Computing structures in Drug Discovery.To buy the whole 6 quantity set, please discuss with ISBN 0-471-37032-0.For a whole record of articles and participants in addition to unfastened pattern chapters from this new sixth variation please stopover at: www.mrw.interscience.wiley.com/bmcdd

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7). Guided by QSAR analysis, the chemists at Kyorin Pharmaceutical Company designed and developed Norfloxacin, a 6-fluoro quinolone, which heralded the arrival of a new class of antibacterial agents (246) (Fig. 7). Two azole-containing fungicides, metconazole (Fig. 8) and ipconazole were launched in 1994 in France and Japan, respectively (247). Lomerizine, a 4-F-benzhydryl-4(2,3,4-trimethoxy benzyl) piperazine, was introduced into the market in 1999 after extensive design strategies using QSAR (248) (Fig.

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J. Livingstone, J. Chem. Znf. Comput. , 40,195 (2000). 3. C. Hansch, A. Kurup, R. Garg, and H. Gao, Chem. , 101,619 (2001). 4. H. Kubinyi in M. , Burger's Medicinal Chemistry and Drug Discovery, Volume 1: Principles and Practice, John Wiley & Sons, New York, 1995, p. 497. 5. A. Crum-Brown and T. R. Fraser, Trans. R. Soc. Edinburgh, 25, 151 (1868). 6. C. Richet and C. R. Seancs, Soc. Biol. Ses. , 9,775 (1893). 7. H. Meyer, Arch. Exp. Pathol. , 42, 109 (1899). 8. E. Overton, Studien Uber die Narkose, Fischer, Jena, Germany, 1901.

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