By Pharmaceutical Press
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Additional info for British National Formulary (BNF) 68
Sample text
04 for women The serum-creatinine concentration is sometimes used instead as a measure of renal function but it is only a rough guide to drug dosing. BNF 68 In the BNF, values for eGFR, creatinine clearance (for toxic drugs), or another measure of renal function are included where possible. However, where such values are not available, the BNF reflects the terms used in the published information. 73 m2 More than 90 (with other evidence of kidney damage) 60–89 (with other evidence of kidney damage) 30–59 15–29 Less than 15 1.
Information on drugs and pregnancy is also available from the UK Teratology Information Service. www. org Important During the second and third trimesters drugs can affect the growth or functional development of the fetus, or they can have toxic effects on fetal tissues. Drugs given shortly before term or during labour can have adverse effects on labour or on the neonate after delivery. The BNF identifies drugs which: . may have harmful effects in pregnancy and indicates the trimester of risk .
Whenever possible use a familiar drug; with a new drug, be particularly alert for adverse reactions or unexpected events; . warn the patient if serious adverse reactions are liable to occur. For established drugs there is no need to report wellknown, relatively minor side-effects, such as dry mouth with tricyclic antidepressants or constipation with opioids. g. cytotoxic drugs and drugs used in anaesthesia). Where causality has not been established, side-effects in the manufacturers’ literature may be omitted from the BNF.