By Jeremy I Levin; Stefan Laufer
Content material: part 1. Arachidonic acid cascade -- part 2. Kinases -- part three. GPCRs -- part four. Sphingolipids -- part five. Steroid hormone receptors
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The fourth quantity within the six-volume instruction manual of Pharmaceutical production Formulations, this publication covers semi-solid medications. It contains formulations of ointments, creams, gels, and suppositories, from publicly to be had yet commonly dispersed details from FDA New Drug functions (NDA), patent purposes, and different assets of commonplace and proprietary formulations.
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45–47 Furthermore, its expression is increased by these cytokines. 1 Role of cytosolic phospholipase A2a in the inﬂammatory cascade. 38 Chapter 2 48 acid of the phospholipid substrate and an active site serine residue. cPLA2a is unique among the PLA2 enzymes in regard of its high selectivity for phospholipids containing arachidonic acid in the sn-2 position. Despite the presence of several phospholipases A2 in the mammalian organism, the pre-eminence of cPLA2a for lipid mediator generation was demonstrated especially by studies with cPLA2a-deﬁcient mice.