By Hans Frauenfelder (auth.), Shirley S. Chan, Winnie S. Chan (eds.)
Physics and the existence sciences have demonstrated new connections in the earlier few a long time, leading to organic physics as a longtime subfield with powerful teams operating in lots of physics departments. those interactions among physics and biology shape a two-way highway with physics supplying new instruments and ideas for realizing existence, whereas organic structures can yield new insights into the physics of advanced structures. to deal with the demanding situations of this interdisciplinary region, The Physics of Proteins: An creation to organic Physics and Molecular Biophysics is split into 3 interconnected sections. In elements I and II, early chapters introduce the terminology and describe the most organic structures that physicists will come upon. Similarities among biomolecules, glasses, and solids are under pressure with an emphasis at the primary suggestions of residing structures. The important part (Parts III and IV) delves into the dynamics of advanced structures. a prime subject is the belief that organic platforms, specifically proteins, don't exist in specific conformations yet can suppose a truly huge variety of a little bit diverse constructions. This complexity is captured within the notion of a unfastened strength panorama and results in the realization that fluctuations are an important for the functioning of organic platforms. the ultimate bankruptcy of this part demanding situations the reader to use those strategies to an issue that looks within the present literature. an in depth sequence of appendices (Part V) offer descriptions of the major actual instruments and analytical tools that experience confirmed strong within the examine of the physics of proteins. The appendices are designed to be consulted during the part on protein dynamics with no breaking the deductive move of the good judgment within the significant element of the book.
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Earnshaw. Cell Biology. Saunders, Philadelphia, 2002. 10. J. J. Hopfield. Kinetic proofreading—new mechanism for reducing errors in biosynthetic processes requiring high specificity. Proc. Natl. Acad. Sci. USA, 71:4135–9, 1974. 11. M. Gueron. Enhanced selectivity of enzymes by kinetic proofreading. Amer. Scientist, 66:202–8, 1978. 12. H. Lodish et al. Molecular Cell Biology, 5th edition. W. H. Freeman, New York, 2004. 13. S. C. R. Elgin and J. L. Workman, editors. Chromatin Structure and Gene Expression.
5. 7 Storage and Retrieval of Information The information encoded on the DNA is useless unless it can be stored and retrieved efficiently [2, 9, 12]–[14]. These tasks are extremely difficult to achieve, as one can realize quickly. 6 × 109 base pairs. 4 ˚ A. The DNA, stretched, thus is about 2 m long, but only about 1 nm in diameter. In the cell, it is compacted into a region with linear dimensions of about 10 µm. How is this compaction achieved, and how can information be extracted from the compact core?
4 ˚ A. The DNA, stretched, thus is about 2 m long, but only about 1 nm in diameter. In the cell, it is compacted into a region with linear dimensions of about 10 µm. How is this compaction achieved, and how can information be extracted from the compact core? It is clear that the packaging must occur hierarchically in a number of steps. Indeed, the first step is reasonably well understood, but the processes beyond the first step, reduction in size by about a factor of ten, are largely unknown. The organization of the first step is sketched in Fig.