Regenerative Strategies for the Treatment of Knee Joint by Joaquim Miguel Oliveira, Rui Luís Reis

By Joaquim Miguel Oliveira, Rui Luís Reis

This publication offers regenerative techniques for the therapy of knee joint disabilities. The booklet consists of 4 major sections totaling 19 chapters which overview the present wisdom at the scientific administration and preclinical regenerative innovations. It examines the position of alternative natural-based biomaterials as scaffolds and implants for addressing diverse tissue lesions within the knee joint. part one offers an up-to-date and complete dialogue on articular cartilage tissue regeneration. part specializes in the $64000 contributions for bone and osteochondral tissue engineering. part 3 evaluate the hot advances on meniscus repair/regeneration suggestions. ultimately, part 4 additional discusses the present ideas for remedy of ligament lesions. every one bankruptcy is ready via global be aware of specialist on their fields, so we do firmly think that the proposed ebook might be a reference within the zone of biomaterials for regenerative medicine.

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Artifacts are related [8, 17, 85]. Fast low-angle shot (FLASH) imaging is an SPGR technique useful for assessment of knee cartilage repair [18, 36, 85]. 3D-DEFT increases contrast between fluid and cartilage and preserve the cartilage signal, resulting in a high signal intensity in both cartilage and synovial liquid [8, 18] but has a long acquisition times with a consequent vulnerability to motion artifacts. 3D-DEFT has a comparable performance to detect cartilage lesions when compared with FSE and SPGR techniques and is not reliable for assessing bone marrow [18, 85].

The synovial fluid lubricates the ends of the bones making possible them to move often. The inefficiency to keep the level of metabolism starts destructive process [16, 17]. Most investigators believe that rheumatoid arthritis is primarily an inflammatory disease of synovial membrane of the joints [18]. The main characteristics of rheumatoid arthritis (RA) are chronic inflammation and progressive joint destruction. The synovial lining layer is thickened and hyperplastic, and synovial villi form.

Sports Med Arthrosc Rev 19(2):82–92 8. Fenn S, Datir A, Saifuddin A (2009) Synovial recesses of the knee: MR imaging review of anatomical and pathological features. Skelet Radiol 38(4):317–328 9. Ralphs J, Benjamin M (1994) The joint capsule: structure, composition, ageing and disease. J Anat 184(Pt 3):503 10. Kiener HP, Karonitsch T (2011) The synovium as a privileged site in rheumatoid arthritis: cadherin-11 as a dominant player in synovial pathology. Best Pract Res Clin Rheumatol 25 (6):767–777 11.

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