Recombinant Dna Vaccines by Richard Isaacson

By Richard Isaacson

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As a result of this advancement of technology, a whole new industry has emerged which has been generically called biotechnology. Impressive new products developed by using recombinant techniques are beginning to enter the marketplace. These products range from biologicals, such as insulin and tissue plasminogen activator, to genetically engineered organisms that can be used to protect valuable fruit crops from freezing, to enzymes utilized in the manufacture of foods, and to new vaccines to be used for hepatitis or fatal diarrhea in livestock.

However, it is not our intention to describe detailed research progress in vaccinology or to provide a manual of techniques on developing a vaccine. The objective of Recombinant DNA Vaccines: Rationale and Strategies is to discuss various aspects of vaccine development within the context of recombinant DNA technology. A variety of books and periodicals describe the development of specific vaccines, some with the aid of rDNA techniques. In this volume we have opted to take a unique approach that focuses on an understanding of why one would want to use these techniques in the first place and how to develop a strategy to accomplish a specific goal.

And Putnev, S. D. (1990). Epitopes recognized by the neutralizing antibodies of an HIV-1 infected individual. J. Immunol. 144:46414647. 15. Berman, P. , Gregory, T. , Nakamura, G. , Champe, M. , Porter, J. , Wurm, F. , Jeshberg, R. , Cobb, E. , and Eichberg, J. W. (1990). Protection of chimpanzees from infection by HIV-1 after vaccination with recombinant glycoprotein gp120 but not gp160. Nature 345:622625. 16. , Kiney, M. -C. (1991). Immunization of chimpanzees confers protection against challenge with human immunodeficiency virus.

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